PMID- 12942698
OWN - NLM
STAT- MEDLINE
DCOM- 20040406
LR  - 20170112
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 21
IP  - 4
DP  - 2003 Jul-Aug
TI  - Serum matrix metalloproteinase 3 levels in comparison to C-reactive protein in 
      periods with and without progression of radiological damage in patients with 
      early rheumatoid arthritis.
PG  - 465-72
AB  - OBJECTIVE: To evaluate serum matrix metalloproteinase 3 (MMP-3) levels in 
      comparison to C-reactive protein (CRP) in periods with and without progression of 
      radiological damage in patients with early rheumatoid arthritis (RA). METHODS: 
      Thirty-two patients with RA and radiological progression (> or = 5 points 
      according to the Sharp/van der Heijde method) during 6 months followed by a 
      6-month period without radiological progression (< or = 1 point) were selected 
      from a prospective follow-up study of early RA patients. Serum MMP-3 levels, CRP, 
      the erythrocyte sedimentation rate (ESR), disease activity index (DAS), swollen 
      joint count (SJC), tender joint count (TJC), and Ritchie articular index (RAI) 
      were measured monthly and results were transformed into mean values for the 
      6-month periods. RESULTS: During the period with radiological progression the 
      mean serum MMP-3 correlated significantly with the mean CRP (r = 0.68, p < 
      0.001), ESR (r = 0.54, p = 0.001) and swollen joint count (r = 0.48, p = 0.006). 
      In the period without radiological progression the mean serum MMP-3 only 
      correlated with the mean CRP (r = 0.44, p = 0.012). Individual changes--expressed 
      in percentages (%)--between the two periods showed a decrease in both the mean 
      serum MMP-3 and CRP in 19 and an increase in 3 patients, in parallel with other 
      markers of disease activity in these patients (69% of cases). The individual 
      change (%) in mean serum MMP-3 or CRP did not correlate with the difference in 
      radiological progression between the two periods. CONCLUSIONS: Serum MMP-3 and 
      CRP are closely related and there seems to be no difference between serum MMP-3 
      and CRP with regard to the monitoring of the progression of radiological damage.
FAU - Posthumus, M D
AU  - Posthumus MD
AD  - Department of Rheumatology, University Hospital Groningen, The Netherlands. 
      m.d.posthumus@int.azg.nl
FAU - Limburg, P C
AU  - Limburg PC
FAU - Westra, J
AU  - Westra J
FAU - van Leeuwen, M A
AU  - van Leeuwen MA
FAU - van Rijswijk, M H
AU  - van Rijswijk MH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/*blood/*diagnostic imaging/physiopathology
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*analysis
MH  - Disease Progression
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Observer Variation
MH  - Probability
MH  - Prospective Studies
MH  - Radiography
MH  - Reference Values
MH  - Sampling Studies
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Time Factors
EDAT- 2003/08/29 05:00
MHDA- 2004/04/07 05:00
CRDT- 2003/08/29 05:00
PHST- 2003/08/29 05:00 [pubmed]
PHST- 2004/04/07 05:00 [medline]
PHST- 2003/08/29 05:00 [entrez]
PST - ppublish
SO  - Clin Exp Rheumatol. 2003 Jul-Aug;21(4):465-72.