PMID- 12944979
OWN - NLM
STAT- MEDLINE
DCOM- 20040409
LR  - 20061115
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 4
IP  - 6
DP  - 2003 Sep
TI  - The TNF-alpha -308, MCP-1 -2518 and TGF-beta1 +915 polymorphisms are not 
      associated with the development of chronic lung disease in very low birth weight 
      infants.
PG  - 420-6
AB  - Chronic lung disease (CLD) in premature newborns is associated with increased 
      concentrations of inflammatory cytokines in tracheal aspirates (TA). We 
      determined if polymorphisms of cytokine genes influence the risk of developing 
      CLD by genotyping 178 mechanically ventilated very low birth weight (VLBW) 
      infants for the tumor necrosis factor-alpha (TNF-alpha) -308 G/A, transforming 
      growth factor-beta(1) (TGF-beta(1)) +915 G/C and monocyte chemoattractant 
      protein-1 (MCP-1) -2518 A/G polymorphisms. Genomic DNA was isolated from TA and 
      genotypes determined by restriction length polymorphism. There was no effect of 
      any of these polymorphisms on the development of CLD (29 vs 23%, P=0.371, 
      TNF-alpha -308 AA/AG vs TNF-alpha -308 GG; 23 vs 26%, P=0.681, MCP-1 -2518 GG/AG 
      vs MCP-1 -215-8 AA; 24 vs 24%, P=0.978, TGF-beta(1) +915 CG vs TGF-beta(1) +915 
      GG). TA IL-8 and MCP-1 concentrations were not different between genotype groups. 
      Infants with the TNF-alpha -308 A allele had increased risk of IVH (RR 2.07; 95% 
      CI 1.02-4.18, P=0.041) and infants with the TGF-beta(1) +915 C allele were at 
      greater risk of death (32 vs 9%, P=0.016). These data suggest that these 
      polymorphisms do not play a significant role in determining risk for CLD in 
      preterm infants, but may play a role in other complications in the neonatal 
      period.
FAU - Adcock, K
AU  - Adcock K
AD  - Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, 
      USA.
FAU - Hedberg, C
AU  - Hedberg C
FAU - Loggins, J
AU  - Loggins J
FAU - Kruger, T E
AU  - Kruger TE
FAU - Baier, R J
AU  - Baier RJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (Chemokine CCL2)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Chronic Disease
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - *Infant, Very Low Birth Weight
MH  - Lung Diseases/etiology/*genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Predictive Value of Tests
MH  - Respiration, Artificial
MH  - Retrospective Studies
MH  - Transforming Growth Factor beta/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2003/08/29 05:00
MHDA- 2004/04/10 05:00
CRDT- 2003/08/29 05:00
PHST- 2003/08/29 05:00 [pubmed]
PHST- 2004/04/10 05:00 [medline]
PHST- 2003/08/29 05:00 [entrez]
AID - 6363986 [pii]
AID - 10.1038/sj.gene.6363986 [doi]
PST - ppublish
SO  - Genes Immun. 2003 Sep;4(6):420-6. doi: 10.1038/sj.gene.6363986.