PMID- 12946694
OWN - NLM
STAT- MEDLINE
DCOM- 20031205
LR  - 20190712
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 121
IP  - 1
DP  - 2003
TI  - Hippocampal brain-derived neurotrophic factor but not neurotrophin-3 increases 
      more in mice selected for increased voluntary wheel running.
PG  - 1-7
AB  - Voluntary wheel running in rats increases hippocampal brain-derived neurotrophic 
      factor (BDNF) expression, a neurochemical important for neuronal survival, 
      differentiation, connectivity and synaptic plasticity. Here, we report the 
      effects of wheel running on BDNF and neurotrophin-3 (NT-3) protein levels in 
      normal control mice, and in mice selectively bred (25 generations) for increased 
      voluntary wheel running. We hypothesized that increased voluntary wheel running 
      in selected (S) mice would increase CNS BDNF and NT-3 protein levels more than in 
      control (C) mice. Baseline hippocampal BDNF levels (mice housed without running 
      wheels) were similar in S and C mice. Following seven nights of running, 
      hippocampal BDNF increased significantly more in S versus C mice, and levels were 
      correlated with distance run (considering C and S mice together). Spinal and 
      cerebellar BDNF and hippocampal NT-3 levels were not significantly affected by 
      wheel running in any group, but there was a small, positive correlation between 
      spinal C3-C6 BDNF levels and distance run (considering C and S mice together). 
      This is the first study to demonstrate that mice which choose to run more have 
      greater elevations in hippocampal BDNF, suggesting enhanced potential for 
      exercise-induced hippocampal neuroplasticity.
FAU - Johnson, R A
AU  - Johnson RA
AD  - Department of Comparative Biosciences, School of Veterinary Medicine, University 
      of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA.
FAU - Rhodes, J S
AU  - Rhodes JS
FAU - Jeffrey, S L
AU  - Jeffrey SL
FAU - Garland, T Jr
AU  - Garland T Jr
FAU - Mitchell, G S
AU  - Mitchell GS
LA  - eng
GR  - HL03874/HL/NHLBI NIH HHS/United States
GR  - HL36780/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Breeding/*methods
MH  - Female
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Motor Activity/*physiology
MH  - Neurotrophin 3/*biosynthesis
EDAT- 2003/08/30 05:00
MHDA- 2003/12/06 05:00
CRDT- 2003/08/30 05:00
PHST- 2003/08/30 05:00 [pubmed]
PHST- 2003/12/06 05:00 [medline]
PHST- 2003/08/30 05:00 [entrez]
AID - S0306452203004226 [pii]
AID - 10.1016/s0306-4522(03)00422-6 [doi]
PST - ppublish
SO  - Neuroscience. 2003;121(1):1-7. doi: 10.1016/s0306-4522(03)00422-6.