PMID- 12947996
OWN - NLM
STAT- MEDLINE
DCOM- 20031002
LR  - 20191107
IS  - 1660-2242 (Print)
IS  - 0079-6034 (Linking)
VI  - 82
DP  - 2003
TI  - Nonspecific plasma proteins during sublingual immunotherapy.
PG  - 99-108
AB  - Usually, specific allergy-related plasma proteins such as immunoglobulin E (IgE) 
      and immunoglobulin G (IgG) are used for estimating the grade of sensitization and 
      follow-up of immunotherapy. In recent years, several nonspecific inflammatory 
      markers, such as sICAM-1 and sIL-2R, have been shown as being suitable for 
      therapy control in allergy. In our investigation of patients under sublingual 
      immunotherapy (SLIT), plasma from 42 healthy controls and 133 children with 
      single inhalation allergies to grass pollen, birch pollen or house dust mites was 
      obtained during the symptom-free period. Patients showed symptoms including 
      allergic rhinitis, dermatitis and allergic asthma with one single RAST class 3 or 
      higher. Plasma concentrations of soluble intercellular adhesion molecule-1 
      (sICAM-1), soluble interleukin-2 receptor (sIL-2R), sE-selectin, interleukin-12 
      (IL-12) and specific IgG4 were analyzed with the ELISA technique. After 1 year of 
      SLIT, concentrations of sICAM-1, sIL-2R and sE-selectin declined significantly 
      when results from all patients were taken as one group. Regarding the single 
      allergen groups, the sICAM-1 and sIL-2R decrease was significant in the grass and 
      mite group, but not in the birch group, while the sE-selectin decline was only 
      significant in the birch group after 1 year of SLIT, but not in the grass and the 
      mite group. No difference was observed in IL-12 and IgG4 expression. In two 
      groups of controls with a mean age of 9.5 versus 17.5 years, the analyzed 
      parameters were not age-dependent. The increased proteins may be useful as 
      additional markers for the evaluation of immunological effects and follow-up 
      investigations of allergy therapies.
FAU - Reich, M
AU  - Reich M
AD  - Department of Dermatology and Allergology, Friedrich Schiller University, Jena, 
      Germany.
FAU - Zwacka, G
AU  - Zwacka G
FAU - Markert, U R
AU  - Markert UR
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Chem Immunol Allergy
JT  - Chemical immunology and allergy
JID - 101183835
RN  - 0 (Allergens)
RN  - 0 (E-Selectin)
RN  - 0 (Receptors, Interleukin-2)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Administration, Sublingual
MH  - Adolescent
MH  - Age Factors
MH  - Allergens/*administration & dosage
MH  - Child
MH  - Child, Preschool
MH  - Desensitization, Immunologic/*methods
MH  - E-Selectin/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/*blood
MH  - Receptors, Interleukin-2/*blood
EDAT- 2003/09/02 05:00
MHDA- 2003/10/03 05:00
CRDT- 2003/09/02 05:00
PHST- 2003/09/02 05:00 [pubmed]
PHST- 2003/10/03 05:00 [medline]
PHST- 2003/09/02 05:00 [entrez]
AID - 10.1159/000071544 [doi]
PST - ppublish
SO  - Chem Immunol Allergy. 2003;82:99-108. doi: 10.1159/000071544.