PMID- 12948504
OWN - NLM
STAT- MEDLINE
DCOM- 20031027
LR  - 20170214
IS  - 1098-612X (Print)
IS  - 1098-612X (Linking)
VI  - 5
IP  - 5
DP  - 2003 Oct
TI  - Pilot study to assess the effects of early flea exposure on the development of 
      flea hypersensitivity in cats.
PG  - 287-94
AB  - This pilot study was to determine if early oral flea exposure reduces the 
      incidence of flea allergy dermatitis (FAD) in cats. Eighteen kittens, assigned to 
      three groups, received no flea exposure, oral flea exposure or flea infestation 
      for 12 weeks. Then all the kittens were exposed continually to fleas for 31 
      weeks. Sensitization was monitored using intradermal testing (IDT), in vitro 
      measurement of anti-flea saliva immunoglobulin E (IgE) and development of FAD. 
      There was no statistically significant difference between groups in IDT 
      reactions, in vitro data or clinical scores. The development of FAD was not 
      associated with the presence of anti-flea saliva IgE. However, the development of 
      a delayed reaction to flea bite was associated with symptoms after flea exposure. 
      Although not statistically significant, the FAD scores in the oral group were 
      lower than in the controls. Further studies are required to determine the role of 
      oral flea exposure in the development of FAD in cats.
FAU - Kunkle, G A
AU  - Kunkle GA
AD  - College of Veterinary Medicine, University of Florida, Gainesville, FL 
      32610-0126, USA. kunkleg@mail.vetmed.ufl.edu
FAU - McCall, C A
AU  - McCall CA
FAU - Stedman, K E
AU  - Stedman KE
FAU - Pilny, A
AU  - Pilny A
FAU - Nicklin, C
AU  - Nicklin C
FAU - Logas, D B
AU  - Logas DB
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Feline Med Surg
JT  - Journal of feline medicine and surgery
JID - 100897329
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Cat Diseases/*immunology/pathology
MH  - Cats
MH  - Dermatitis, Allergic Contact/immunology/veterinary
MH  - Ectoparasitic Infestations/immunology/*veterinary
MH  - Enzyme-Linked Immunosorbent Assay/veterinary
MH  - Female
MH  - Hypersensitivity, Delayed/immunology/*veterinary
MH  - Immunoglobulin E/blood
MH  - Intradermal Tests/veterinary
MH  - Male
MH  - Pilot Projects
MH  - Siphonaptera/*immunology
EDAT- 2003/09/02 05:00
MHDA- 2003/10/28 05:00
CRDT- 2003/09/02 05:00
PHST- 2003/09/02 05:00 [pubmed]
PHST- 2003/10/28 05:00 [medline]
PHST- 2003/09/02 05:00 [entrez]
AID - S1098612X03000263 [pii]
AID - 10.1016/S1098-612X(03)00026-3 [doi]
PST - ppublish
SO  - J Feline Med Surg. 2003 Oct;5(5):287-94. doi: 10.1016/S1098-612X(03)00026-3.