PMID- 12948915
OWN - NLM
STAT- MEDLINE
DCOM- 20031208
LR  - 20061115
IS  - 1167-1122 (Print)
IS  - 1167-1122 (Linking)
VI  - 13
IP  - 4
DP  - 2003 Jul-Aug
TI  - Identification of retroviral DNA sequences in serum of cutaneous forms of lupus 
      erythematosus patients.
PG  - 354-8
AB  - Discoid (DLE), discoid disseminated (DDLE) and subacute cutaneous lupus 
      erythematosus (SCLE) are recognised as cutaneous forms of lupus erythematosus 
      (LE). It has been suggested that expression of endogenous retroviral components 
      might induce the biosynthesis of antiDNA antibodies in LE patients. Using the dot 
      blot hybridisation, we detected the greatest correlation between biosynthesis of 
      anti-double stranded DNA (anti-dsDNA), anti-single stranded DNA (anti-ssDNA) 
      antibodies and the presence of human immunodeficiency virus type I (HIV-1) pol 
      sequences in DNA isolated from serum of SCLE (n = 22) patients. The same studies 
      conducted in the groups of DLE (n = 85) and DDLE (n = 51) patients, exhibited a 
      lower correlation between production of anti-dsDNA, anti-ssDNA and the presence 
      of homologous HIV-1 pol sequences than in SCLE patients. Our findings suggest 
      that the presence of endogenous retroviral sequences in patient serum may exhibit 
      a relationship with development of cutaneous forms of LE disease.
FAU - Prokop, Janusz
AU  - Prokop J
AD  - Department of Dermatology, University of Medical Sciences, 6 Swiecickiego St., 
      60-781 Poznan, Poland.
FAU - Jagodzinski, Pawel P
AU  - Jagodzinski PP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Dermatol
JT  - European journal of dermatology : EJD
JID - 9206420
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Single-Stranded)
RN  - 0 (DNA, Viral)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Antibodies, Antinuclear/*blood
MH  - Case-Control Studies
MH  - DNA/blood/*immunology
MH  - DNA Primers
MH  - DNA, Single-Stranded/blood/*immunology
MH  - DNA, Viral/*blood
MH  - HIV-1/*genetics/isolation & purification
MH  - Humans
MH  - Immunoblotting
MH  - Lupus Erythematosus, Cutaneous/blood/*virology
MH  - Lupus Erythematosus, Discoid/blood/virology
EDAT- 2003/09/02 05:00
MHDA- 2003/12/09 05:00
CRDT- 2003/09/02 05:00
PHST- 2003/09/02 05:00 [pubmed]
PHST- 2003/12/09 05:00 [medline]
PHST- 2003/09/02 05:00 [entrez]
PST - ppublish
SO  - Eur J Dermatol. 2003 Jul-Aug;13(4):354-8.