PMID- 1295073
OWN - NLM
STAT- MEDLINE
DCOM- 19930415
LR  - 20131121
IS  - 0891-7035 (Print)
IS  - 0891-7035 (Linking)
VI  - 6
IP  - 4
DP  - 1992 Dec
TI  - Response of the esophageal epithelium to concomitant 
      cis-dichlorodiammineplatinum(II) and radiation treatment. An electron microscopic 
      study in rabbits.
PG  - 1023-33; discussion 1033-4
AB  - The rabbit esophageal mucosa was irradiated with daily fractions of 2 Gy up to an 
      accumulated dose of 20 Gy (total dose 2, 6, 10. 16 or 20 Gy). Fifteen to 
      forty-five minutes before the start of each irradiation 0.3 mg 
      Cis-dichlorodiammineplatinum (cis-DDP, cisplatinum) was given by intraperitoneal 
      injection to each rabbit. Examinations were carried out 1-10 days after each 
      fractionation schedule, when specimens were taken for morphological 
      investigations. Scanning electron microscope (SEM) examination showed a gradual 
      development of damage with cell loss and structural disarrangement of the 
      microridges and whorls on the surface. However, with further treatment the 
      esophageal mucosa exposed to cis-DDP and radiation normalized faster and more 
      complete compared to the esophageal part exposed to cis-DDP alone. The difference 
      may depend on an accelerated proliferation in the part of the trachea that is 
      exposed to a combined treatment.
FAU - Albertsson, M
AU  - Albertsson M
AD  - Department of Oncology, University Hospital, Lund, Sweden.
FAU - Cwikiel, M
AU  - Cwikiel M
FAU - Hakansson, C H
AU  - Hakansson CH
FAU - Palmegren, M
AU  - Palmegren M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Scanning Microsc
JT  - Scanning microscopy
JID - 8704616
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Animals
MH  - Cell Division/drug effects/radiation effects
MH  - Cisplatin/*pharmacology
MH  - Epithelium/drug effects/radiation effects/ultrastructure
MH  - Esophagus/drug effects/radiation effects/*ultrastructure
MH  - *Microscopy, Electron
MH  - *Microscopy, Electron, Scanning
MH  - Mucous Membrane/ultrastructure
MH  - Rabbits
EDAT- 1992/12/01 00:00
MHDA- 1992/12/01 00:01
CRDT- 1992/12/01 00:00
PHST- 1992/12/01 00:00 [pubmed]
PHST- 1992/12/01 00:01 [medline]
PHST- 1992/12/01 00:00 [entrez]
PST - ppublish
SO  - Scanning Microsc. 1992 Dec;6(4):1023-33; discussion 1033-4.