PMID- 12951169
OWN - NLM
STAT- MEDLINE
DCOM- 20040511
LR  - 20190906
IS  - 0009-9120 (Print)
IS  - 0009-9120 (Linking)
VI  - 36
IP  - 6
DP  - 2003 Sep
TI  - Hyperhomocysteinemia and its role in the development of atherosclerosis.
PG  - 431-41
AB  - Numerous epidemiological studies have demonstrated that hyperhomocysteinemia 
      (HHcy) is a strong and independent risk factor for cardiovascular disease. HHcy 
      can result from a deficiency in the enzymes or vitamin cofactors required for 
      homocysteine metabolism. Several hypotheses have been proposed to explain the 
      cellular mechanisms by which HHcy promotes cardiovascular disease, including 
      oxidative stress, endoplasmic reticulum (ER) stress and the activation of 
      pro-inflammatory factors. Studies using genetic- and diet-induced animal models 
      of HHcy have now demonstrated a direct causal relationship between HHcy, 
      endothelial dysfunction and accelerated atherosclerosis. These recently 
      established animal models of HHcy provide investigators with important in vivo 
      tools to (i) further understand the cellular mechanisms by which HHcy contributes 
      to endothelial dysfunction and atherosclerosis, and (ii) develop therapeutic 
      agents useful in the treatment of cardiovascular disease.
FAU - Lawrence de Koning, A B
AU  - Lawrence de Koning AB
AD  - Department of Pathology and Molecular Medicine, McMaster University and the 
      Henderson Research Centre, Hamilton, Ontario, Canada.
FAU - Werstuck, Geoff H
AU  - Werstuck GH
FAU - Zhou, Ji
AU  - Zhou J
FAU - Austin, Richard C
AU  - Austin RC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Chemokine CCL2)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Animals
MH  - Aorta/pathology
MH  - Arteriosclerosis/genetics/*metabolism/pathology
MH  - Chemokine CCL2/analysis/metabolism
MH  - Diet
MH  - Endoplasmic Reticulum/metabolism
MH  - Endothelium, Vascular/metabolism/pathology
MH  - Homocysteine/blood/metabolism/urine
MH  - Humans
MH  - Hyperhomocysteinemia/genetics/*metabolism
MH  - Models, Animal
MH  - Oxidative Stress
MH  - Risk Factors
RF  - 126
EDAT- 2003/09/03 05:00
MHDA- 2004/05/12 05:00
CRDT- 2003/09/03 05:00
PHST- 2003/09/03 05:00 [pubmed]
PHST- 2004/05/12 05:00 [medline]
PHST- 2003/09/03 05:00 [entrez]
AID - S0009912003000626 [pii]
AID - 10.1016/s0009-9120(03)00062-6 [doi]
PST - ppublish
SO  - Clin Biochem. 2003 Sep;36(6):431-41. doi: 10.1016/s0009-9120(03)00062-6.