PMID- 12953273
OWN - NLM
STAT- MEDLINE
DCOM- 20031023
LR  - 20220409
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 54
IP  - 3
DP  - 2003 Sep
TI  - Monocyte chemoattractant protein-1 increases microglial infiltration and 
      aggressiveness of gliomas.
PG  - 388-92
AB  - Macrophages are thought to represent a first line of defense in anti-tumor 
      immunity. Despite infiltration by microglial cells, however, malignant gliomas 
      are still highly aggressive tumors. We here identify monocyte chemoattractant 
      protein-1 (MCP-1) as a critical chemoattractant for glioma-infiltrating 
      microglial cells. MCP-1-transfected rat CNS-1 gliomas were massively infiltrated 
      by microglial cells. Whereas MCP-1 did not promote the growth of CNS-1 cells in 
      vitro, intracerebral CNS-1-transfected tumors grew more aggressively than 
      control-transfected tumors. This provides the first functional evidence that 
      MCP-1 recruits microglial cells to gliomas and promotes their growth in vivo. 
      Microglial cells may support rather than suppress glioma growth.
FAU - Platten, Michael
AU  - Platten M
AD  - Laboratory of Molecular Neuro-Oncology, Department of Neurology, University of 
      Tubingen Medical School, Hoppe-Seyler-Strasse 3, 72076 Tubingen, Germany.
FAU - Kretz, Alexandra
AU  - Kretz A
FAU - Naumann, Ulrike
AU  - Naumann U
FAU - Aulwurm, Steffen
AU  - Aulwurm S
FAU - Egashira, Kensuke
AU  - Egashira K
FAU - Isenmann, Stefan
AU  - Isenmann S
FAU - Weller, Michael
AU  - Weller M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (Chemokine CCL2)
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/*physiology
MH  - Chemotaxis
MH  - Corpus Striatum/transplantation
MH  - Culture Media, Conditioned/pharmacology
MH  - Female
MH  - Glioma/metabolism
MH  - Microglia/*metabolism
MH  - Neoplasm Invasiveness
MH  - Neoplasm Transplantation
MH  - Neurons/drug effects/metabolism
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Wistar
MH  - Transfection
MH  - Tumor Cells, Cultured
EDAT- 2003/09/04 05:00
MHDA- 2003/10/24 05:00
CRDT- 2003/09/04 05:00
PHST- 2003/09/04 05:00 [pubmed]
PHST- 2003/10/24 05:00 [medline]
PHST- 2003/09/04 05:00 [entrez]
AID - 10.1002/ana.10679 [doi]
PST - ppublish
SO  - Ann Neurol. 2003 Sep;54(3):388-92. doi: 10.1002/ana.10679.