PMID- 12954220
OWN - NLM
STAT- MEDLINE
DCOM- 20031028
LR  - 20190714
IS  - 0042-6822 (Print)
IS  - 1096-0341 (Electronic)
IS  - 0042-6822 (Linking)
VI  - 313
IP  - 2
DP  - 2003 Sep 1
TI  - Epitope specificity is critical for high and moderate avidity cytotoxic T 
      lymphocytes associated with control of viral load and clinical disease in horses 
      with equine infectious anemia virus.
PG  - 537-52
AB  - Equine infectious anemia virus (EIAV) is a lentivirus that causes persistent 
      infections in horses. We hypothesized that high-avidity CTL specific for 
      nonvariable epitopes might be associated with low viral load and minimal disease 
      in EIAV-infected horses. To test this hypothesis, memory CTL (CTLm) responses 
      were analyzed in two infected horses with high plasma viral loads and recurrent 
      disease (progressors), and in two infected horses with low-to-undetectable viral 
      loads and mild disease (nonprogressors). High-avidity CTLm in one progressor 
      recognized an envelope gp90 epitope, and the data documented for the first time 
      in EIAV that viral variation led to CTL escape. Each of the nonprogressors had 
      high-to-moderate avidity CTLm directed against epitopes within Rev, including the 
      nuclear export and nuclear localization domains. These results suggested that the 
      epitope specificity of high- and moderate-avidity CTLm was an important 
      determinant for disease outcome in the EIAV-infected horses examined.
FAU - Mealey, Robert H
AU  - Mealey RH
AD  - Department of Veterinary Microbiology and Pathology, Washington State University, 
      Pullman, WA 99164-7040, USA. rhm@vetmed.wsu.edu
FAU - Zhang, Baoshan
AU  - Zhang B
FAU - Leib, Steven R
AU  - Leib SR
FAU - Littke, Matt H
AU  - Littke MH
FAU - McGuire, Travis C
AU  - McGuire TC
LA  - eng
SI  - GENBANK/AY288550
SI  - GENBANK/AY288551
SI  - GENBANK/AY288552
SI  - GENBANK/AY288553
SI  - GENBANK/AY288554
SI  - GENBANK/AY288555
SI  - GENBANK/AY288556
SI  - GENBANK/AY288557
SI  - GENBANK/AY288558
SI  - GENBANK/AY288559
SI  - GENBANK/AY288606
SI  - GENBANK/AY288607
SI  - GENBANK/AY288608
SI  - GENBANK/AY288609
SI  - GENBANK/AY288610
SI  - GENBANK/AY288611
SI  - GENBANK/AY288612
SI  - GENBANK/AY288613
SI  - GENBANK/AY288614
SI  - GENBANK/AY288615
SI  - GENBANK/AY288616
SI  - GENBANK/AY288617
SI  - GENBANK/AY288618
SI  - GENBANK/AY288619
SI  - GENBANK/AY288620
SI  - GENBANK/AY288621
SI  - GENBANK/AY288622
SI  - GENBANK/AY288623
SI  - GENBANK/AY288624
SI  - GENBANK/AY288625
SI  - GENBANK/AY288626
SI  - GENBANK/AY288627
SI  - GENBANK/AY288628
SI  - GENBANK/AY288629
SI  - GENBANK/AY288630
SI  - GENBANK/AY288631
SI  - GENBANK/AY288632
SI  - GENBANK/AY288633
SI  - GENBANK/AY288634
SI  - GENBANK/AY288635
SI  - GENBANK/AY288636
SI  - GENBANK/AY288637
SI  - GENBANK/AY288638
SI  - GENBANK/AY288639
SI  - GENBANK/AY288640
SI  - GENBANK/AY288641
SI  - GENBANK/AY288642
SI  - GENBANK/AY288643
SI  - GENBANK/AY288644
SI  - GENBANK/AY288645
SI  - GENBANK/AY288646
SI  - GENBANK/AY288647
SI  - GENBANK/AY288648
SI  - GENBANK/AY288649
GR  - K08 AI001575/AI/NIAID NIH HHS/United States
GR  - AI01575/AI/NIAID NIH HHS/United States
GR  - AI24291/AI/NIAID NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (Glycoproteins)
RN  - 0 (RNA, Viral)
RN  - 0 (SU protein, equine infectious anemia virus)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Disease Progression
MH  - Epitope Mapping
MH  - Epitopes, T-Lymphocyte/*immunology
MH  - Equine Infectious Anemia/diagnosis/*immunology/virology
MH  - Fever/veterinary
MH  - Glycoproteins/genetics/*immunology
MH  - Horses
MH  - Immunologic Memory
MH  - *Infectious Anemia Virus, Equine/chemistry
MH  - Molecular Sequence Data
MH  - RNA, Viral/analysis
MH  - Sequence Alignment
MH  - T-Lymphocytes, Cytotoxic/*immunology
MH  - Thrombocytopenia/veterinary
MH  - Viral Envelope Proteins/genetics/*immunology
MH  - Viral Load/veterinary
PMC - PMC3342690
MID - NIHMS373287
EDAT- 2003/09/05 05:00
MHDA- 2003/10/29 05:00
PMCR- 2012/05/03
CRDT- 2003/09/05 05:00
PHST- 2003/09/05 05:00 [pubmed]
PHST- 2003/10/29 05:00 [medline]
PHST- 2003/09/05 05:00 [entrez]
PHST- 2012/05/03 00:00 [pmc-release]
AID - S0042682203003441 [pii]
AID - 10.1016/s0042-6822(03)00344-1 [doi]
PST - ppublish
SO  - Virology. 2003 Sep 1;313(2):537-52. doi: 10.1016/s0042-6822(03)00344-1.