PMID- 12954454
OWN - NLM
STAT- MEDLINE
DCOM- 20030930
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 73
IP  - 19
DP  - 2003 Sep 26
TI  - Treadmill exercise suppresses ischemia-induced increment in apoptosis and cell 
      proliferation in hippocampal dentate gyrus of gerbils.
PG  - 2455-65
AB  - Cerebral ischemia resulting from transient or permanent occlusion of cerebral 
      arteries leads to neuronal cell death and eventually causes neurological 
      impairments. In the present study, the effects of treadmill exercise on apoptosis 
      and cell proliferation in the hippocampal dentate gyrus following transient 
      global ischemia in gerbils were investigated using terminal deoxynucleotidyl 
      transferase-mediated dUTP nick end labeling (TUNEL) assay and 
      immunohistochemistry for caspase-3 and 5-bromo-2'-deoxyuridine (BrdU). It was 
      shown that apoptotic cell death and cell proliferation in the hippocampal dentate 
      gyrus were significantly increased following transient global ischemia in gerbils 
      and that treadmill exercise suppressed the ischemia-induced increase in apoptosis 
      and cell proliferation in the dentate gyrus. The present results suggest that 
      treadmill exercise may protect cells from apoptotic death and aid in recovery 
      from the central nervous system sequelae following stroke.
FAU - Lee, Myoung-Hwa
AU  - Lee MH
AD  - Research Institute of Sports Science, Korea University, #1 5-Ka Anam-dong, 
      Sungbuk-ku, Seoul 136-701 South Korea.
FAU - Kim, Hong
AU  - Kim H
FAU - Kim, Sung-Soo
AU  - Kim SS
FAU - Lee, Taeck-Hyun
AU  - Lee TH
FAU - Lim, Baek-Vin
AU  - Lim BV
FAU - Chang, Hyun-Kyung
AU  - Chang HK
FAU - Jang, Mi-Hyeon
AU  - Jang MH
FAU - Shin, Min-Chul
AU  - Shin MC
FAU - Shin, Mal-Soon
AU  - Shin MS
FAU - Kim, Chang-Ju
AU  - Kim CJ
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Cell Division/physiology
MH  - Dentate Gyrus/*pathology
MH  - Disease Models, Animal
MH  - Gerbillinae
MH  - In Situ Nick-End Labeling
MH  - Ischemic Attack, Transient/pathology/*physiopathology
MH  - Male
MH  - Physical Conditioning, Animal
MH  - *Physical Exertion
EDAT- 2003/09/05 05:00
MHDA- 2003/10/01 05:00
CRDT- 2003/09/05 05:00
PHST- 2003/09/05 05:00 [pubmed]
PHST- 2003/10/01 05:00 [medline]
PHST- 2003/09/05 05:00 [entrez]
AID - S0024320503006556 [pii]
AID - 10.1016/s0024-3205(03)00655-6 [doi]
PST - ppublish
SO  - Life Sci. 2003 Sep 26;73(19):2455-65. doi: 10.1016/s0024-3205(03)00655-6.