PMID- 12955414
OWN - NLM
STAT- MEDLINE
DCOM- 20040116
LR  - 20131121
IS  - 0300-5860 (Print)
IS  - 0300-5860 (Linking)
VI  - 92
IP  - 8
DP  - 2003 Aug
TI  - Effect of bisoprolol on perioperative complications in chronic heart failure 
      after surgery (Cardiac Insufficiency Bisoprolol Study II (CIBIS II)).
PG  - 668-76
AB  - In patients with coronary artery disease undergoing noncardiac surgery, 
      beta-blockers decrease perioperative mortality and nonfatal myocardial 
      infarction. It is presently unknown whether beta-blockers reduce perioperative 
      risk in patients with chronic heart failure. Thus, data of the CIBIS II study 
      were analyzed regarding the effect of bisoprolol on perioperative outcome in 
      patients with moderate to severe heart failure. A total of 2647 patients with 
      heart failure in New York Heart Association (NYHA) class III-IV and left 
      ventricular ejection fraction < or =35% were randomized to bisoprolol or placebo 
      in a double-blind randomized study. Of these patients, 165 underwent surgery 
      (bisoprolol, n = 87; placebo, n = 78). In patients undergoing surgery, mortality 
      was not different between the placebo- and bisoprolol-treated group (7.7% vs 
      5.8%, p = 0.76). Neither postoperative hospital admission (placebo, 24.4%; 
      bisoprolol, 34.5%, p = 0.17) nor time to postoperative hospital admission 
      (placebo, < or =30 days, n = 2; 31-180 days, n=11; >180 days, n = 6; bisoprolol, 
      n = 9/ 10/11; p = 0.14) were reduced by bisoprolol. Compared to coronary artery 
      disease, perioperative beta-blockade has little effect in patients with chronic 
      heart failure. Therefore, a controlled randomized trial with perioperative 
      beta-blocker treatment in heart failure patients is warranted to further test 
      this hypothesis.
FAU - Bohm, M
AU  - Bohm M
AD  - Universitatskliniken des Saarlandes, Medizinische Klinik und Poliklinik, Innere 
      Medizin III, 66421 Homburg/Saar, Germany. boehm@med-in.uni-saarland.de
FAU - Maack, C
AU  - Maack C
FAU - Wehrlen-Grandjean, M
AU  - Wehrlen-Grandjean M
FAU - Erdmann, E
AU  - Erdmann E
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Z Kardiol
JT  - Zeitschrift fur Kardiologie
JID - 0360430
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Placebos)
RN  - Y41JS2NL6U (Bisoprolol)
SB  - IM
MH  - Adrenergic beta-Antagonists/administration & dosage/*pharmacology/therapeutic use
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bisoprolol/administration & dosage/*pharmacology/therapeutic use
MH  - Data Interpretation, Statistical
MH  - Double-Blind Method
MH  - Female
MH  - Heart Failure/*complications/drug therapy/mortality
MH  - Hospitalization
MH  - Humans
MH  - Intraoperative Complications/mortality/*prevention & control
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Placebos
MH  - Risk Factors
MH  - Stroke Volume
MH  - *Surgical Procedures, Operative/mortality
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2003/09/05 05:00
MHDA- 2004/01/17 05:00
CRDT- 2003/09/05 05:00
PHST- 2003/01/06 00:00 [received]
PHST- 2003/04/30 00:00 [accepted]
PHST- 2003/09/05 05:00 [pubmed]
PHST- 2004/01/17 05:00 [medline]
PHST- 2003/09/05 05:00 [entrez]
AID - 10.1007/s00392-003-0959-7 [doi]
PST - ppublish
SO  - Z Kardiol. 2003 Aug;92(8):668-76. doi: 10.1007/s00392-003-0959-7.