PMID- 12956308
OWN - NLM
STAT- MEDLINE
DCOM- 20031209
LR  - 20200423
IS  - 1050-0545 (Print)
IS  - 1050-0545 (Linking)
VI  - 14
IP  - 5
DP  - 2003 Jul
TI  - Potential contamination effects of neuronal refractoriness on the speech-evoked 
      mismatch negativity response.
PG  - 251-9
AB  - The mismatch negativity response (MMN) is an event-related potential that is 
      believed to reflect the automatic (possibly preconscious) neural processing of 
      changes in ongoing environmental sounds. The MMN involves a negative voltage 
      shift of baseline electroencephalographic (EEG) activity in the approximate 
      latency window of the N1 and P2 cortical potentials in response to new or novel 
      sounds. The most commonly used laboratory tests for extracting the MMN from EEG 
      activity all involve oddball stimulus presentation procedures in which the 
      interstimulus intervals (ISIs) of the frequently occurring standard sounds are 
      shorter in length then that of the infrequently occurring deviant sounds. This 
      presents the possibility that the MMN response could be affected by neuronal 
      refractory or recovery events. The present study tested 12 young females, using 
      the syllabic events /da/ and /ga/ as standard and deviant stimuli, and found 
      evidence that, with certain experimental protocols, ISI-dependent neural 
      refractory effects can affect the morphology of the MMN, possibly resulting in 
      misinterpretation of the underlying neural bases of the response.
FAU - Cranford, Jerry L
AU  - Cranford JL
AD  - Department of Communication Sciences and Disorders, East Carolina University, 
      Greenville, North Carolina, USA. jcranf@lsuhsc.edu
FAU - Walker, Letitia J
AU  - Walker LJ
FAU - Stuart, Andrew
AU  - Stuart A
FAU - Elangovan, Saravanan
AU  - Elangovan S
FAU - Pravica, David
AU  - Pravica D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Audiol
JT  - Journal of the American Academy of Audiology
JID - 9114646
SB  - IM
MH  - Adult
MH  - Electroencephalography
MH  - Evoked Potentials, Auditory/*physiology
MH  - Female
MH  - Hearing/*physiology
MH  - Humans
MH  - Neurons/*physiology
MH  - *Refractory Period, Electrophysiological
EDAT- 2003/09/06 05:00
MHDA- 2003/12/11 05:00
CRDT- 2003/09/06 05:00
PHST- 2003/09/06 05:00 [pubmed]
PHST- 2003/12/11 05:00 [medline]
PHST- 2003/09/06 05:00 [entrez]
PST - ppublish
SO  - J Am Acad Audiol. 2003 Jul;14(5):251-9.