PMID- 12956743
OWN - NLM
STAT- MEDLINE
DCOM- 20031215
LR  - 20190901
IS  - 0954-7894 (Print)
IS  - 0954-7894 (Linking)
VI  - 33
IP  - 9
DP  - 2003 Sep
TI  - Family history and risk of atopic dermatitis in children up to 4 years.
PG  - 1226-31
AB  - BACKGROUND: The aetiology of atopic dermatitis (AD) is presumably 
      multi-factorial, with interactions between genetic and environmental factors. 
      OBJECTIVE: To investigate the relation between atopic family history and 
      development of AD up to 4 years. METHODS: Using annual questionnaires, we studied 
      the cumulative incidence of AD in 0-4-year-olds in a prospective birth cohort of 
      4089. Atopic diseases in parents and siblings were recorded at birth. The 
      occurrence of serum immunoglobulin E (IgE) antibodies to inhalant and food 
      allergens was analysed in 2614 4-year-olds, and AD was divided into 
      non-IgE-associated and IgE-associated. RESULTS: Of the children without atopic 
      parents, 27.1% developed AD; of those with single or double parental atopic 
      history, 37.9% and 50.0%, respectively, did so. The effects of parental history 
      of eczema and of atopic respiratory disease (ARD) did not differ significantly, 
      nor did those of maternal and paternal history. Parental history of ARD increased 
      the risk significantly more for IgE-associated AD than for non-IgE-associated AD 
      (odds ratio (OR) 2.0; 95% confidence interval (CI) 1.5-2.8 vs. OR 1.3; 95% CI 
      1.0-1.8), whereas the two forms lacked major differences in the effect of 
      parental eczema. A history of eczema in older siblings was a risk indicator for 
      both forms of AD (OR 2.1; 95% CI 1.4-3.3 vs. OR 1.8; 95% CI 1.2-2.6). 
      CONCLUSIONS: We found no difference between the effects of maternal and paternal 
      atopic history. Parental eczema was a risk factor for AD irrespective of its 
      association with IgE, but parental history of ARD mainly increased the risk of 
      IgE-associated AD.
FAU - Bohme, M
AU  - Bohme M
AD  - Department of Dermatology and Venereology, Karolinska Hospital and Karolinska 
      Institutet, Stockholm, Sweden. Maria.Bohme@ood.ki.se
FAU - Wickman, M
AU  - Wickman M
FAU - Lennart Nordvall, S
AU  - Lennart Nordvall S
FAU - Svartengren, M
AU  - Svartengren M
FAU - Wahlgren, C F
AU  - Wahlgren CF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Dermatitis, Atopic/*genetics/immunology
MH  - Eczema/genetics
MH  - *Family
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - Male
MH  - Odds Ratio
MH  - Parents
MH  - Prospective Studies
MH  - Respiratory Hypersensitivity/genetics
MH  - Risk Factors
MH  - Surveys and Questionnaires
EDAT- 2003/09/06 05:00
MHDA- 2003/12/16 05:00
CRDT- 2003/09/06 05:00
PHST- 2003/09/06 05:00 [pubmed]
PHST- 2003/12/16 05:00 [medline]
PHST- 2003/09/06 05:00 [entrez]
AID - 1749 [pii]
AID - 10.1046/j.1365-2222.2003.01749.x [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2003 Sep;33(9):1226-31. doi: 10.1046/j.1365-2222.2003.01749.x.