PMID- 12957262
OWN - NLM
STAT- MEDLINE
DCOM- 20031023
LR  - 20190708
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 57
IP  - 2
DP  - 2003 Oct 1
TI  - Influence of radiation therapy delay on abdominal tumor recurrence in patients 
      with favorable histology Wilms' tumor treated on NWTS-3 and NWTS-4: a report from 
      the National Wilms' Tumor Study Group.
PG  - 495-9
AB  - PURPOSE: This study was undertaken to determine whether radiation therapy (RT) 
      delay of >or=10 days had an adverse impact on abdominal tumor recurrence among 
      children with favorable histology (FH) Wilms' tumor enrolled in National Wilms' 
      Tumor Study (NWTS) 3 and 4. METHODS AND MATERIALS: A total of 1226 patients with 
      Stage II-IV FH tumors who received flank or abdominal RT in NWTS-3 and NWTS-4 
      were included in this analysis. Recurrent disease in the operative bed was 
      classified as flank recurrence. Abdominal recurrence included all 
      infradiaphragmatic tumor recurrences, including flank recurrences. This analysis 
      included all flank/abdominal tumor recurrences, regardless of whether they might 
      have been the initial or subsequent site of relapse. Based on the NWTS-1 results, 
      RT delay was analyzed in two categories: 0-9 days and >or=10 days. RESULTS: The 
      mean RT delay was 10.9 days; median delay was 9 days (range: 1-277 days). The RT 
      delay was concentrated in a relatively narrow range of 8 to 12 days after 
      nephrectomy in the majority of patients (59%). Univariate and multivariate 
      analysis did not reveal RT delay of >or=10 days to significantly influence flank 
      and abdominal tumor recurrence rates in NWTS-3 or NWTS-4. The 8-year flank tumor 
      recurrence rates for 0-9 days and 10+ days RT delay were 1.9% and 1.2%, 
      respectively (p value = 0.3). The 8-year abdominal tumor recurrence rates for 0-9 
      days and 10+ days RT delay were 4.8% and 5.3%, respectively (p value = 0.7). 
      CONCLUSIONS: RT delay of >or=10 days did not significantly influence flank or 
      abdominal tumor recurrence rates among children with FH tumors treated on NWTS-3 
      and NWTS-4. However, we were unable to test for a meaningful difference, because 
      of the concentration of RT delay close to 10 days.
FAU - Kalapurakal, John A
AU  - Kalapurakal JA
AD  - Robert H. Lurie Cancer Center, Northwestern University, Chicago, IL, USA. 
      j-kalapurakal@northwestern.edu
FAU - Li, Sierra M
AU  - Li SM
FAU - Breslow, Norman E
AU  - Breslow NE
FAU - Beckwith, J Bruce
AU  - Beckwith JB
FAU - Macklis, Roger
AU  - Macklis R
FAU - Thomas, Patrick R M
AU  - Thomas PR
FAU - D'Angio, Guilio J
AU  - D'Angio GJ
FAU - Kim, Tae
AU  - Kim T
FAU - de Lorimier, Alfred
AU  - de Lorimier A
FAU - Kelalis, Panayotis
AU  - Kelalis P
FAU - Shochat, Steven
AU  - Shochat S
FAU - Ritchey, Michael
AU  - Ritchey M
FAU - Haase, Gerald
AU  - Haase G
FAU - Hrabovsky, Ellen
AU  - Hrabovsky E
FAU - Otherson, H Biemann
AU  - Otherson HB
FAU - Grundy, Paul
AU  - Grundy P
FAU - Green, Daniel M
AU  - Green DM
CN  - National Wilms' Tumor Study Group
LA  - eng
GR  - CA-42326/CA/NCI NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Abdominal Neoplasms/secondary
MH  - Adolescent
MH  - Analysis of Variance
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Kidney Neoplasms/pathology/*radiotherapy/surgery
MH  - Male
MH  - Neoplasm Recurrence, Local
MH  - Neoplasm Staging
MH  - Nephrectomy
MH  - Time Factors
MH  - Wilms Tumor/pathology/*radiotherapy/surgery
EDAT- 2003/09/06 05:00
MHDA- 2003/10/24 05:00
CRDT- 2003/09/06 05:00
PHST- 2003/09/06 05:00 [pubmed]
PHST- 2003/10/24 05:00 [medline]
PHST- 2003/09/06 05:00 [entrez]
AID - S0360301603005984 [pii]
AID - 10.1016/s0360-3016(03)00598-4 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2003 Oct 1;57(2):495-9. doi: 
      10.1016/s0360-3016(03)00598-4.