PMID- 12958665
OWN - NLM
STAT- MEDLINE
DCOM- 20031218
LR  - 20191107
IS  - 0873-2159 (Print)
IS  - 0873-2159 (Linking)
VI  - 9
IP  - 1
DP  - 2003 Jan-Feb
TI  - [Morphometric intratumoral microvessel area evaluation could be a useful 
      indicator for coadjuvant therapy in ressected NSCLC].
PG  - 19-32
AB  - OBJECTIVE: To accomplish the tumor vascular area measure and the microvessel 
      count, shown by immunohistochemistry, in non small cell lung cancer (NSCLC) 
      microscopic images, and verify the correlation between these measurements and 
      patients survival. DESIGN: cross-sectional and observational. MATERIAL AND 
      METHODS: The material was deriving from 107 NSCLC surgical specimens in Pavilhao 
      Pereira Filho Santa Casa, Porto Alegre. Immunohistochemistry with anti-CD 34 
      monoclonal antibody (QB-End10; DAKO Corporation) was performed on 
      paraffin-embedded tissue sections. The tumoral vascular area and the microvessel 
      count were obtained by Image Pro Plus 3.0 program. RESULTS: The 5-year survival 
      rate of high vascular area group (the cut-off was the mean of areas) was 21.7 
      months +/- 2.5, significantly lower (P < 0.0001) than the low vascular area 
      cases, 38.9 months +/- 3.0. The correlation coefficient between microvessel area 
      and microvessel count was 0.5 (P = 0.001). The tumoral vascular area shown higher 
      correlation to survival (correlation coefficient: 0.48 / P = 0.001) than the 
      tumoral microvessel count (correlation coefficient: 0.2 / P = 0.03). There was 
      not any significant correlation between the microvessel areas and the 
      histological type, the TNM, the lymph nodes status and the clinical staging. 
      CONCLUSION: The tumoral vascular area measurement, with computed assistance, can 
      be used as a prognostic marker in NSCLC.
FAU - Irion, Luciane Cristina Dreher
AU  - Irion LC
AD  - Faculdade Federal de Ciencias Medicas de Porto Alegre (FFFCMPA). Porto Alegre, 
      RS, Brasil.
FAU - Prolla, Joao Carlos
AU  - Prolla JC
FAU - Hartmann, Antonio Atalibio
AU  - Hartmann AA
FAU - da Silva, Vinicius Duval
AU  - da Silva VD
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - A determinacao quantitativa da area de microvasos intratumorais pode ser um 
      indicador util para tratamento coadjuvante em carcinomas de celulas nao pequenas 
      operados do pulmao.
PL  - Spain
TA  - Rev Port Pneumol
JT  - Revista portuguesa de pneumologia
JID - 9813736
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Non-Small-Cell Lung/*blood supply/mortality/*pathology/surgery
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*blood supply/mortality/*pathology/surgery
MH  - Male
MH  - Microcirculation
MH  - Middle Aged
MH  - Survival Rate
EDAT- 2003/09/06 05:00
MHDA- 2003/12/19 05:00
CRDT- 2003/09/06 05:00
PHST- 2003/09/06 05:00 [pubmed]
PHST- 2003/12/19 05:00 [medline]
PHST- 2003/09/06 05:00 [entrez]
AID - S0873-2159(15)30650-4 [pii]
AID - 10.1016/s0873-2159(15)30650-4 [doi]
PST - ppublish
SO  - Rev Port Pneumol. 2003 Jan-Feb;9(1):19-32. doi: 10.1016/s0873-2159(15)30650-4.