PMID- 12959223
OWN - NLM
STAT- MEDLINE
DCOM- 20040402
LR  - 20190922
IS  - 0271-9142 (Print)
IS  - 0271-9142 (Linking)
VI  - 23
IP  - 4
DP  - 2003 Jul
TI  - Placental abruption is associated with decreased maternal plasma levels of 
      soluble HLA-G.
PG  - 307-14
AB  - During pregnancy the fetus represents a semi-allograft. Both membrane-bound and 
      soluble forms of the nonclassic human leukocyte antigen (HLA)-G protect the fetus 
      from maternal immune attack. To assess the relevance of soluble HLA-G (sHLA-G) 
      levels in the maternal circulation for the occurrence of characteristic pregnancy 
      disorders, we analyzed sHLA-G plasma levels of women with normal and pathological 
      pregnancies. Compared to normal pregnancy, significantly increased sHLA-G levels 
      were detected in women delivered preterm because of intrauterine activation 
      (uncontrollable labor, rupture of fetal membranes, cervical insufficiency) and 
      women with Hemolysis, Elevated Liver enzymes, Low Platelet count (HELLP) 
      syndrome. Contrary to these disorders, the sHLA-G levels in women with placental 
      abruption were more than three times lower than in normal pregnancy (p < .0001). 
      Nonparametric discriminant analysis showed that women with sHLA-G levels below 
      9.95 ng/mL had a relative risk of 7.12 for the development of placental abruption 
      during further course of pregnancy. These results suggest that the occurrence of 
      pregnancy-associated diseases is strongly influenced by maternal sHLA-G plasma 
      levels.
FAU - Steinborn, A
AU  - Steinborn A
AD  - Department of Obstetrics and Gynecology, University of Frankfurt, Frankfurt/Main, 
      Germany. steinborn@em.uni-frankfurt.de
FAU - Rebmann, V
AU  - Rebmann V
FAU - Scharf, A
AU  - Scharf A
FAU - Sohn, C
AU  - Sohn C
FAU - Grosse-Wilde, H
AU  - Grosse-Wilde H
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Clin Immunol
JT  - Journal of clinical immunology
JID - 8102137
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Abruptio Placentae/*immunology
MH  - Alleles
MH  - Female
MH  - HELLP Syndrome/immunology
MH  - HLA Antigens/*blood
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*blood
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications/immunology
MH  - Pregnancy Trimester, Second
MH  - Pregnancy Trimester, Third
MH  - Solubility
EDAT- 2003/09/10 05:00
MHDA- 2004/04/03 05:00
CRDT- 2003/09/10 05:00
PHST- 2003/09/10 05:00 [pubmed]
PHST- 2004/04/03 05:00 [medline]
PHST- 2003/09/10 05:00 [entrez]
AID - 10.1023/a:1024592901663 [doi]
PST - ppublish
SO  - J Clin Immunol. 2003 Jul;23(4):307-14. doi: 10.1023/a:1024592901663.