PMID- 12962428
OWN - NLM
STAT- MEDLINE
DCOM- 20030926
LR  - 20150901
IS  - 1607-551X (Print)
IS  - 1607-551X (Linking)
VI  - 19
IP  - 8
DP  - 2003 Aug
TI  - Potential role of vascular endothelial growth factor, interleukin-8 and monocyte 
      chemoattractant protein-1 in periodontal diseases.
PG  - 406-15
AB  - Host-mediated immunoinflammatory pathways activated by bacteria lead to 
      destruction of the periodontal connective tissues and alveolar bone. The 
      objective of this study was to elucidate the activation of the inflammatory 
      processes in periodontal disease by quantitative assessment of cytokines and 
      periodontopathogens. Gingival crevicular fluids (GCF) and subgingival plaque 
      samples were collected from patients with chronic periodontitis and gingivitis 
      and from periodontally healthy sites. Vascular endothelial growth factor (VEGF), 
      monocyte chemoattractant protein-1 (MCP-1), and interleukin 8 (IL-8) in GCF were 
      analyzed by enzyme-linked immunosorbent assay. Periodontopathogens, including 
      Bacteroides forsythus, Campylobacter rectus, Porphyromonas gingivalis and 
      Prevotella intermedia, were analyzed by immunofluorescence and dark-field 
      microscopy. There was significantly more VEGF and IL-8 in chronic periodontitis 
      and gingivitis sites than in periodontally healthy sites. There were significant 
      positive correlations between the concentrations and total amounts of VEGF and 
      IL-8 in chronic periodontitis and gingivitis sites, and between the levels of 
      periodontopathogens and the total amounts of VEGF, MCP-1 and IL-8. These data 
      indicate that inflammatory processes induced by periodontopathogens and the 
      activation of certain cytokines (VEGF, MCP-1, IL-8) in periodontal diseases may 
      be relevant to host-mediated destruction in chronic periodontitis.
FAU - Lee, En
AU  - Lee E
AD  - Graduate Institute of Dental Sciences, College of Dental Medicine, Kaohsiung 
      Medical University, Kaohsiung, Taiwan.
FAU - Yang, Yi-Hsin
AU  - Yang YH
FAU - Ho, Ya-Ping
AU  - Ho YP
FAU - Ho, Kun-Yen
AU  - Ho KY
FAU - Tsai, Chi-Cheng
AU  - Tsai CC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China (Republic : 1949- )
TA  - Kaohsiung J Med Sci
JT  - The Kaohsiung journal of medical sciences
JID - 100960562
RN  - 0 (Chemokine CCL2)
RN  - 0 (Endothelial Growth Factors)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Interleukin-8)
RN  - 0 (Lymphokines)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factors)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/analysis/*physiology
MH  - Endothelial Growth Factors/analysis/*physiology
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/analysis/*physiology
MH  - Interleukin-8/analysis/*physiology
MH  - Lymphokines/analysis/*physiology
MH  - Middle Aged
MH  - Periodontal Diseases/*etiology/immunology
MH  - Vascular Endothelial Growth Factor A
MH  - Vascular Endothelial Growth Factors
EDAT- 2003/09/10 05:00
MHDA- 2003/09/27 05:00
CRDT- 2003/09/10 05:00
PHST- 2003/09/10 05:00 [pubmed]
PHST- 2003/09/27 05:00 [medline]
PHST- 2003/09/10 05:00 [entrez]
AID - S1607-551X(09)70484-X [pii]
AID - 10.1016/S1607-551X(09)70484-X [doi]
PST - ppublish
SO  - Kaohsiung J Med Sci. 2003 Aug;19(8):406-15. doi: 10.1016/S1607-551X(09)70484-X.