PMID- 12962719
OWN - NLM
STAT- MEDLINE
DCOM- 20031021
LR  - 20191026
IS  - 0301-472X (Print)
IS  - 0301-472X (Linking)
VI  - 31
IP  - 9
DP  - 2003 Sep
TI  - Minor histocompatibility antigens in human stem cell transplantation.
PG  - 743-51
AB  - Minor histocompatibility antigens (mHags) play a major role in graft rejection, 
      the induction of detrimental graft-vs-host disease (GVHD), and the development of 
      the beneficial graft-vs-leukemia (GVL) effect after allogeneic stem cell 
      transplantation (SCT). mHags can be defined as amino acid polymorphisms in 
      cellular proteins that can lead to differential presentation of antigenic 
      peptides in HLA molecules and therefore to differential recognition by T cells. 
      The tissue distribution of the mHags and the HLA molecules by which they can be 
      presented play a significant role in the clinical outcome of T-cell responses 
      against these antigens. In part, differential recognition by T cells of mHags 
      specifically expressed in hematopoietic cells, including the malignant cells from 
      the recipient may result in GVL reactivity without concurrent GVHD. Furthermore, 
      T-cell responses against proteins solely expressed in hematopoietic cell lineages 
      from which the malignancy is derived may be appropriate mediators of GVL 
      reactivity without GVHD induction. Characterization of clinical immune responses 
      in patients treated for relapsed leukemia after allogeneic SCT with donor 
      lymphocyte infusion in the absence of GVHD may lead to the characterization of 
      new mHags that can be exploited to generate tumor-specific immune responses. By 
      in vitro generation of T-cell responses against defined mHags, the efficacy and 
      specificity of cellular immunotherapy against hematologic malignancies in the 
      context of allogeneic transplantation may be improved.
FAU - Falkenburg, J H Frederik
AU  - Falkenburg JH
AD  - Department of Hematology, Leiden University Medical Center, Leiden, The 
      Netherlands. falkenburg.hematology@lumc.nl
FAU - van de Corput, Lisette
AU  - van de Corput L
FAU - Marijt, Erik W A
AU  - Marijt EW
FAU - Willemze, Roel
AU  - Willemze R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Exp Hematol
JT  - Experimental hematology
JID - 0402313
RN  - 0 (Minor Histocompatibility Antigens)
SB  - IM
MH  - Graft Rejection/etiology/immunology
MH  - Graft vs Host Disease/etiology/immunology
MH  - Graft vs Leukemia Effect/immunology
MH  - Humans
MH  - Minor Histocompatibility Antigens/*immunology
MH  - *Stem Cell Transplantation
MH  - *Transplantation Immunology
MH  - Transplantation, Homologous
RF  - 67
EDAT- 2003/09/10 05:00
MHDA- 2003/10/22 05:00
CRDT- 2003/09/10 05:00
PHST- 2003/09/10 05:00 [pubmed]
PHST- 2003/10/22 05:00 [medline]
PHST- 2003/09/10 05:00 [entrez]
AID - S0301472X03001905 [pii]
AID - 10.1016/s0301-472x(03)00190-5 [doi]
PST - ppublish
SO  - Exp Hematol. 2003 Sep;31(9):743-51. doi: 10.1016/s0301-472x(03)00190-5.