PMID- 12962903
OWN - NLM
STAT- MEDLINE
DCOM- 20031110
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 350
IP  - 1
DP  - 2003 Oct 16
TI  - Altered trkB neurotrophin receptor activation does not influence the 
      N-methyl-D-aspartate receptor antagonist-mediated neurotoxicity in mouse 
      posterior cingulate cortex.
PG  - 1-4
AB  - Non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists produce toxic 
      effects in the limbic cortex of rodent brain. NMDA antagonists also increase the 
      expression of brain-derived neurotrophic factor (BDNF) mRNA in the same brain 
      areas. The aim of this study was to investigate whether increased BDNF signalling 
      plays a role in the NMDA-mediated toxic effect by using transgenic mice with 
      modified BDNF signalling and HSP-70 expression as an indicator of toxicity. 
      Neither the enhanced nor the reduced trkB activity influenced MK-801-induced 
      neurotoxic effects in the posterior cingulate cortex of mouse brain, which 
      indicates that increased BDNF production neither protects nor exacerbates 
      neurotoxic effects of NMDA receptor antagonists.
FAU - Vaisanen, Jussi
AU  - Vaisanen J
AD  - A.I. Virtanen Institute, University of Kuopio, Kuopio, Finland.
FAU - Saarelainen, Tommi
AU  - Saarelainen T
FAU - Koponen, Eija
AU  - Koponen E
FAU - Castren, Eero
AU  - Castren E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (Phosphorus Isotopes)
RN  - 0 (Protein Isoforms)
RN  - 0 (RNA, Messenger)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Behavior, Animal/drug effects
MH  - Dizocilpine Maleate/*pharmacology
MH  - Excitatory Amino Acid Antagonists/*pharmacology
MH  - Gene Expression/drug effects
MH  - Gyrus Cinguli/anatomy & histology/*drug effects/metabolism
MH  - HSP70 Heat-Shock Proteins/genetics/metabolism
MH  - In Situ Hybridization
MH  - Mice
MH  - Mice, Transgenic
MH  - Motor Activity/drug effects
MH  - Oligonucleotides, Antisense/metabolism
MH  - Phosphorus Isotopes
MH  - Protein Isoforms/genetics
MH  - RNA, Messenger/analysis
MH  - Receptor, trkB/genetics/*metabolism
EDAT- 2003/09/10 05:00
MHDA- 2003/11/11 05:00
CRDT- 2003/09/10 05:00
PHST- 2003/09/10 05:00 [pubmed]
PHST- 2003/11/11 05:00 [medline]
PHST- 2003/09/10 05:00 [entrez]
AID - S0304394003007444 [pii]
AID - 10.1016/s0304-3940(03)00744-4 [doi]
PST - ppublish
SO  - Neurosci Lett. 2003 Oct 16;350(1):1-4. doi: 10.1016/s0304-3940(03)00744-4.