PMID- 12963148
OWN - NLM
STAT- MEDLINE
DCOM- 20040317
LR  - 20190901
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 88
IP  - 2-3
DP  - 2003 Oct
TI  - Inhibitory effects of Xanthii fructus extract on mast cell-mediated allergic 
      reaction in murine model.
PG  - 229-34
AB  - The effect of aqueous extract of Xanthii fructus (XF) on mast cell-mediated 
      allergic reaction has been investigated. XF inhibited compound 48/80-induced 
      systemic anaphylaxis in mouse. This dose-dependently inhibited histamine release 
      from rat peritoneal mast cells (RPMC) by compound 48/80. Additionally, XF 
      inhibited local immunoglobulin E (IgE)-mediated passive cutaneous anaphylatic 
      reaction. When XF (0.1mg/ml) was added, the secretion of tumor necrosis 
      factor-alpha (TNF-alpha) from anti-dinitrophenyl (DNP) IgE antibody-stimulated 
      mast cells was inhibited by 56%. Our studies provide evidence that XF may be 
      beneficial in the treatment of various types allergic diseases.
FAU - Hong, Seung-Heon
AU  - Hong SH
AD  - Department of Oriental Pharmacy, College of Pharmacy, VCRC of Wonkwang 
      University, Iksan, Jeonbuk 570-749, South Korea.
FAU - Jeong, Hyun-Ja
AU  - Jeong HJ
FAU - Kim, Hyung-Min
AU  - Kim HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Dinitrophenols)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
SB  - IM
MH  - Anaphylaxis/*drug therapy/immunology
MH  - Animals
MH  - Anti-Allergic Agents/isolation & purification/*pharmacology
MH  - Asteraceae/*chemistry
MH  - Dinitrophenols/immunology
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Immunologic
MH  - Histamine Release/drug effects
MH  - Immunoglobulin E/administration & dosage
MH  - Male
MH  - Mast Cells/drug effects/*immunology/metabolism
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Plant Extracts/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/biosynthesis
MH  - p-Methoxy-N-methylphenethylamine/administration & dosage
EDAT- 2003/09/10 05:00
MHDA- 2004/03/18 05:00
CRDT- 2003/09/10 05:00
PHST- 2003/09/10 05:00 [pubmed]
PHST- 2004/03/18 05:00 [medline]
PHST- 2003/09/10 05:00 [entrez]
AID - S0378874103002320 [pii]
AID - 10.1016/s0378-8741(03)00232-0 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2003 Oct;88(2-3):229-34. doi: 10.1016/s0378-8741(03)00232-0.