PMID- 12963865
OWN - NLM
STAT- MEDLINE
DCOM- 20031030
LR  - 20131121
IS  - 1090-0535 (Electronic)
IS  - 1090-0535 (Linking)
VI  - 9
DP  - 2003 Sep 2
TI  - MICA association with presumed ocular histoplasmosis syndrome (POHS).
PG  - 420-4
AB  - PURPOSE: MHC class I chain related gene A (MICA), a polymorphic and 
      stress-inducible cell surface molecule, is located centromeric to human leukocyte 
      antigen locus B (HLA-B) in the human leukocyte antigen (HLA) region on chromosome 
      6. MICA is thought to be involved in the innate immune response. An alanine 
      repeat polymorphism is present in the MICA transmembrane region, for which 
      several disease associations have been reported. Previous research indicated an 
      association with the HLA-B7-DR2 haplotype. In this study we investigated the 
      association of the polymorphic MICA alanine repeat and the ocular disease 
      presumed ocular histoplasmosis syndrome (POHS). METHODS: Twenty-four patients and 
      106 controls were evaluated for the alanine repeat. A PCR reaction was performed 
      to amplify the polymorphic MICA alanine repeat. Allele lengths of the MICA 
      alanine repeat in patients and controls were determined with GeneScan analysis. 
      RESULTS: No significant associations were observed. Phenotype frequencies of the 
      polymorphic MICA alanine repeat were not significantly different between POHS 
      patients and controls. Neither in the complete patient group compared with the 
      control group nor in one of the subdivided patient groups compared with the 
      control group. CONCLUSIONS: We conclude that the MICA alanine repeat is not a 
      disease-associated factor in POHS. Further analysis of other genes in the B-DR 
      region might elucidate the association of POHS with B7-DR2.
FAU - Reinders, Judith
AU  - Reinders J
AD  - Department of Pathology, University Medical Centre Utrecht, Utrecht, The 
      Netherlands.
FAU - Rozemuller, Erik H
AU  - Rozemuller EH
FAU - Ongkosuwito, Jenny V
AU  - Ongkosuwito JV
FAU - Jager, Martine J
AU  - Jager MJ
FAU - Tilanus, Marcel G J
AU  - Tilanus MG
FAU - Suttorp-Schulten, Maria S A
AU  - Suttorp-Schulten MS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20030902
PL  - United States
TA  - Mol Vis
JT  - Molecular vision
JID - 9605351
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
RN  - 0 (Membrane Proteins)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Adult
MH  - Alanine/*genetics
MH  - Eye Infections, Fungal/*genetics/microbiology
MH  - Female
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histoplasma/*isolation & purification
MH  - Histoplasmosis/*genetics/microbiology
MH  - Humans
MH  - Male
MH  - Membrane Proteins/genetics
MH  - Microsatellite Repeats/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Retinal Diseases/*genetics/microbiology
MH  - Syndrome
EDAT- 2003/09/10 05:00
MHDA- 2003/10/31 05:00
CRDT- 2003/09/10 05:00
PHST- 2003/09/10 05:00 [pubmed]
PHST- 2003/10/31 05:00 [medline]
PHST- 2003/09/10 05:00 [entrez]
AID - v9/a54 [pii]
PST - epublish
SO  - Mol Vis. 2003 Sep 2;9:420-4.