PMID- 12964117
OWN - NLM
STAT- MEDLINE
DCOM- 20031015
LR  - 20221207
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 188
IP  - 6
DP  - 2003 Sep 15
TI  - Influence of human leukocyte antigen-B22 alleles on the course of human 
      immunodeficiency virus type 1 infection in 3 cohorts of white men.
PG  - 856-63
AB  - The human leukocyte antigen (HLA)-B22 serogroup--which consists of the alleles 
      B*54, B*55, and B*56--has been associated with rapidly progressive disease in 
      white patients with human immunodeficiency virus (HIV) infection. Subjects from 3 
      cohorts of men who have sex with men (N=671), all of whom experienced HIV-1 
      seroconversion at roughly the same time, were molecularly typed at HLA-A, -B, and 
      -C loci. Mean HIV RNA loads during early HIV infection were higher in 
      B22-positive men than in B22-negative men (difference, 0.481 log(10) HIV RNA 
      copies/mL; 95% confidence interval [CI], 0.156-0.806 log(10) HIV RNA copies/mL; 
      P=.004). Independent of accepted markers of progression, time-to-AIDS was shorter 
      in B22-positive seroconverters (adjusted hazard ratio, 1.98; 95% CI, 1.27-3.10; 
      P=.003). White B22 serogroup alleles (B*55 and *56) appear to predispose to 
      unfavorable outcome of HIV infection as strongly as some or all B*35 and B*53 
      alleles. This finding may have greater implications for Asians, because the 
      marker frequency for B22 is higher among Asians than among whites (approximately 
      10% vs. approximately 4%).
FAU - Dorak, M Tevfik
AU  - Dorak MT
AD  - Department of Epidemiology, University of Alabama at Birmingham, Alabama, USA.
FAU - Tang, Jianming
AU  - Tang J
FAU - Tang, Shenghui
AU  - Tang S
FAU - Penman-Aguilar, Ana
AU  - Penman-Aguilar A
FAU - Coutinho, Roel A
AU  - Coutinho RA
FAU - Goedert, James J
AU  - Goedert JJ
FAU - Detels, Roger
AU  - Detels R
FAU - Kaslow, Richard A
AU  - Kaslow RA
LA  - eng
GR  - 5-M01-RR-00722/RR/NCRR NIH HHS/United States
GR  - R01 AI41951/AI/NIAID NIH HHS/United States
GR  - U01-AI-35039/AI/NIAID NIH HHS/United States
GR  - U01-AI-35040/AI/NIAID NIH HHS/United States
GR  - U01-AI-35041/AI/NIAID NIH HHS/United States
GR  - U01-AI-35042/AI/NIAID NIH HHS/United States
GR  - U01-AI-35043/AI/NIAID NIH HHS/United States
GR  - U01-AI-37613/AI/NIAID NIH HHS/United States
GR  - U01-AI-37984/AI/NIAID NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20030903
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B22 antigen)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Cohort Studies
MH  - Disease Progression
MH  - *Genetic Predisposition to Disease
MH  - HIV Infections/*genetics/*physiopathology
MH  - HIV-1/pathogenicity
MH  - HLA-B Antigens/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Proportional Hazards Models
MH  - RNA, Viral/blood
MH  - Viral Load
MH  - *White People
EDAT- 2003/09/10 05:00
MHDA- 2003/10/16 05:00
CRDT- 2003/09/10 05:00
PHST- 2002/10/15 00:00 [received]
PHST- 2003/04/03 00:00 [accepted]
PHST- 2003/09/10 05:00 [pubmed]
PHST- 2003/10/16 05:00 [medline]
PHST- 2003/09/10 05:00 [entrez]
AID - JID30204 [pii]
AID - 10.1086/378071 [doi]
PST - ppublish
SO  - J Infect Dis. 2003 Sep 15;188(6):856-63. doi: 10.1086/378071. Epub 2003 Sep 3.