PMID- 12964808
OWN - NLM
STAT- MEDLINE
DCOM- 20040511
LR  - 20161018
IS  - 1434-6621 (Print)
IS  - 1434-6621 (Linking)
VI  - 41
IP  - 8
DP  - 2003 Aug
TI  - Clinical B12 deficiency in one case of recurrent spontaneous pregnancy loss.
PG  - 1026-7
AB  - Moderate hyperhomocysteinaemia (HHcy) and the homozygous mutation C677T in the 
      5,10-methylenetetrahydrofolate reductase (MTHFR) gene are associated with 
      increased risk of recurrent pregnancy loss. This HHcy is currently reported as a 
      consequence of folate rather than of vitamin B12-deficient status. We describe 
      one case of recurrent early pregnancy loss with HHcy caused by B12 deficiency. A 
      38-year old woman had four episodes of early spontaneous pregnancy loss. 
      Biological data: no haemostasis disorders, HHcy (25.9 micromol/l), normal folate 
      (5 ng/ml), B12 deficiency (< 150 pg/ml) and the MTHFR C677T homozygote genotype. 
      A bone marrow biopsy gave evidence of moderate megaloblastosis. Parenteral B12 
      therapy led to normal homocysteine level within 2 months and to a successful 
      pregnancy. In conclusion, vitamin B12 deficiency is one of the causes of 
      recurrent pregnancy loss associated with HHcy, and serum B12 should be measured 
      systematically in this circumstance.
FAU - Candito, Mirande
AU  - Candito M
AD  - INSERM U 145, Department of Biochemistry, Hopital Pasteur, Nice, France. 
      candito.m@chu-nice.fr
FAU - Magnaldo, Sarah
AU  - Magnaldo S
FAU - Bayle, Jacques
AU  - Bayle J
FAU - Dor, Jean-Francois
AU  - Dor JF
FAU - Gillet, Yves
AU  - Gillet Y
FAU - Bongain, Andre
AU  - Bongain A
FAU - Van Obberghen, Emmanuel
AU  - Van Obberghen E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Abortion, Habitual/blood/*etiology
MH  - Adult
MH  - Female
MH  - Folic Acid/blood
MH  - Homozygote
MH  - Humans
MH  - Hyperhomocysteinemia/blood
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/genetics
MH  - Mutation/genetics
MH  - Vitamin B 12 Deficiency/blood/*complications
EDAT- 2003/09/11 05:00
MHDA- 2004/05/12 05:00
CRDT- 2003/09/11 05:00
PHST- 2003/09/11 05:00 [pubmed]
PHST- 2004/05/12 05:00 [medline]
PHST- 2003/09/11 05:00 [entrez]
AID - 10.1515/CCLM.2003.157 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2003 Aug;41(8):1026-7. doi: 10.1515/CCLM.2003.157.