PMID- 12965188
OWN - NLM
STAT- MEDLINE
DCOM- 20040511
LR  - 20191107
IS  - 1532-0456 (Print)
IS  - 1532-0456 (Linking)
VI  - 135
IP  - 4
DP  - 2003 Aug
TI  - Effects of 2,4-D and its metabolite 2,4-dichlorophenol on antioxidant enzymes and 
      level of glutathione in human erythrocytes.
PG  - 435-41
AB  - The effects of in vitro exposure of human erythrocytes to different 
      concentrations of 2,4-dichlorophenoxyacetic acid (2,4-D) and its metabolite 
      2,4-dichlorophenol (2,4-DCP) were studied. The activity of superoxide dismutase 
      (SOD), glutathione peroxidase (GSH-Px) and the level of reduced glutathione (GSH) 
      were determined. The activity of erythrocyte superoxide dismutase SOD decreased 
      with increasing dose of 2,4-D and 2,4-DCP, while glutathione peroxidase activity 
      increased. 2,4-D (500 ppm) decreased the level of reduced glutathione in 
      erythrocytes by 18% and 2,4-DCP (250 ppm) by 32%, respectively, in comparison 
      with the controls. These results lead to the conclusion that in vitro 
      administration of herbicide-2,4-D and its metabolite 2,4-DCP causes a decrease in 
      the level of reduced glutathione in erythrocytes and significant changes in 
      antioxidant enzyme activities. Comparison of the toxicity of 2,4-D and 2,4-DCP 
      revealed that the most prominent changes occurred in human erythrocytes incubated 
      with 2,4-DCP.
FAU - Bukowska, Bozena
AU  - Bukowska B
AD  - Department of Biophysics of Environmental Pollution, University of Lodz, Banacha 
      12/16, 90-237 Lodz, Poland. bukow@biol.uni.lodz.pl
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Comp Biochem Physiol C Toxicol Pharmacol
JT  - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
JID - 100959500
RN  - 0 (Anthelmintics)
RN  - 0 (Chlorophenols)
RN  - 0 (Herbicides)
RN  - 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - 2,4-Dichlorophenoxyacetic Acid/*toxicity
MH  - Anthelmintics/toxicity
MH  - Chlorophenols/*toxicity
MH  - Erythrocytes/*drug effects/*metabolism
MH  - Glutathione/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Herbicides/toxicity
MH  - Humans
MH  - Superoxide Dismutase/metabolism
EDAT- 2003/09/11 05:00
MHDA- 2004/05/12 05:00
CRDT- 2003/09/11 05:00
PHST- 2003/09/11 05:00 [pubmed]
PHST- 2004/05/12 05:00 [medline]
PHST- 2003/09/11 05:00 [entrez]
AID - S1532045603001510 [pii]
AID - 10.1016/s1532-0456(03)00151-0 [doi]
PST - ppublish
SO  - Comp Biochem Physiol C Toxicol Pharmacol. 2003 Aug;135(4):435-41. doi: 
      10.1016/s1532-0456(03)00151-0.