PMID- 12966217
OWN - NLM
STAT- MEDLINE
DCOM- 20031030
LR  - 20171101
IS  - 0378-5866 (Print)
IS  - 0378-5866 (Linking)
VI  - 25
IP  - 2-4
DP  - 2003 Mar-Aug
TI  - Differential regulation of thalamic and cortical axonal growth by hepatocyte 
      growth factor/scatter factor.
PG  - 197-206
AB  - The initial axonal projections between the cerebral cortex and thalamus are 
      established during embryogenesis. Chemoattractants and repellents are thought to 
      provide specific guidance cues for directional growth of these pathways. 
      Hepatocyte growth factor/scatter factor (HGF/SF) serves as an attractant for 
      developing motor neurons, and its distribution in embryonic pallidum, pallium and 
      thalamus suggests a similar role in forebrain development. We examined the 
      effectiveness of HGF/SF in regulating thalamic and cortical neuronal growth using 
      in vitro assays. HGF/SF increased neurite outgrowth of thalamic, but not cortical 
      neurons, grown in dissociated cultures or as explants. HGF/SF also exhibited a 
      chemoattractant property for thalamic axons, promoting the extension of neurites 
      towards an HGF/SF source. These experiments demonstrate HGF/SF has the capacity 
      to selectively direct thalamocortical projections into an intermediate target, 
      the pallidum, and eventually to their final cortical destination.
CI  - Copyright 2003 S. Karger AG, Basel
FAU - Powell, Elizabeth M
AU  - Powell EM
AD  - Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, 
      PA 15213, USA. epowell@pitt.edu
FAU - Muhlfriedel, Sven
AU  - Muhlfriedel S
FAU - Bolz, Jurgen
AU  - Bolz J
FAU - Levitt, Pat
AU  - Levitt P
LA  - eng
GR  - MH12651/MH/NIMH NIH HHS/United States
GR  - MH45507/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Dev Neurosci
JT  - Developmental neuroscience
JID - 7809375
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Cerebral Cortex/drug effects/embryology
MH  - Female
MH  - Hepatocyte Growth Factor/genetics/*pharmacology
MH  - Humans
MH  - Immunoblotting
MH  - Immunohistochemistry
MH  - Mice
MH  - Neural Pathways/drug effects/*embryology
MH  - Neurites/*drug effects/physiology
MH  - Neurons/diagnostic imaging/drug effects/physiology
MH  - Pregnancy
MH  - Proto-Oncogene Proteins c-met/metabolism
MH  - Rats
MH  - Thalamus/drug effects/embryology
MH  - Transfection
MH  - Ultrasonography
EDAT- 2003/09/11 05:00
MHDA- 2003/10/31 05:00
CRDT- 2003/09/11 05:00
PHST- 2003/02/25 00:00 [received]
PHST- 2003/04/01 00:00 [accepted]
PHST- 2003/09/11 05:00 [pubmed]
PHST- 2003/10/31 05:00 [medline]
PHST- 2003/09/11 05:00 [entrez]
AID - 72268 [pii]
AID - 10.1159/000072268 [doi]
PST - ppublish
SO  - Dev Neurosci. 2003 Mar-Aug;25(2-4):197-206. doi: 10.1159/000072268.