PMID- 12967485
OWN - NLM
STAT- MEDLINE
DCOM- 20031105
LR  - 20240404
IS  - 1080-6040 (Print)
IS  - 1080-6059 (Electronic)
IS  - 1080-6040 (Linking)
VI  - 9
IP  - 8
DP  - 2003 Aug
TI  - Porcine reproductive and respiratory syndrome virus: origin hypothesis.
PG  - 903-8
AB  - Porcine reproductive and respiratory syndrome is a serious swine disease that 
      appeared suddenly in the midwestern United States and central Europe 
      approximately 14 years ago; the disease has now spread worldwide. In North 
      America and Europe, the syndrome is caused by two genotypes of porcine 
      reproductive and respiratory syndrome virus (PRRSV), an arterivirus whose genomes 
      diverge by approximately 40%. My hypothesis, which explains the origin and 
      evolution of the two distinct PRRSV genotypes, is that a mutant of a closely 
      related arterivirus of mice (lactate dehydrogenase-elevating virus) infected wild 
      boars in central Europe. These wild boars functioned as intermediate hosts and 
      spread the virus to North Carolina in imported, infected European wild boars in 
      1912; the virus then evolved independently on the two continents in the prevalent 
      wild hog populations for approximately 70 years until independently entering the 
      domestic pig population.
FAU - Plagemann, Peter G W
AU  - Plagemann PG
AD  - University of Minnesota, Minneapolis, Minnesota 55455, USA. plage001@umn.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Emerg Infect Dis
JT  - Emerging infectious diseases
JID - 9508155
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Genotype
MH  - Lactate dehydrogenase-elevating virus/*genetics
MH  - Porcine Reproductive and Respiratory Syndrome/epidemiology/*transmission
MH  - Porcine respiratory and reproductive syndrome virus/*genetics
MH  - Prevalence
MH  - Swine
PMC - PMC3020618
EDAT- 2003/09/12 05:00
MHDA- 2003/11/06 05:00
PMCR- 2003/08/01
CRDT- 2003/09/12 05:00
PHST- 2003/09/12 05:00 [pubmed]
PHST- 2003/11/06 05:00 [medline]
PHST- 2003/09/12 05:00 [entrez]
PHST- 2003/08/01 00:00 [pmc-release]
AID - 03-0232 [pii]
AID - 10.3201/eid0908.030232 [doi]
PST - ppublish
SO  - Emerg Infect Dis. 2003 Aug;9(8):903-8. doi: 10.3201/eid0908.030232.