PMID- 12968931
OWN - NLM
STAT- MEDLINE
DCOM- 20031120
LR  - 20190916
IS  - 0033-7587 (Print)
IS  - 0033-7587 (Linking)
VI  - 160
IP  - 4
DP  - 2003 Oct
TI  - Biological effectiveness of accelerated particles for the induction of chromosome 
      damage measured in metaphase and interphase human lymphocytes.
PG  - 425-35
AB  - Chromosome aberrations were investigated in human lymphocytes after in vitro 
      exposure to 1H-, 3He-, 12C-, 40Ar-, 28Si-, 56Fe-, or 197Au-ion beams, with LET 
      ranging from approximately 0.4-1393 keV/microm in the dose range of 0.075-3 Gy. 
      Dose-response curves for chromosome exchanges, measured at the first mitosis 
      postirradiation using fluorescence in situ hybridization (FISH) with 
      whole-chromosome probes, were fitted with linear or linear-quadratic functions. 
      The relative biological effectiveness (RBE) was estimated from the initial slope 
      of the dose-response curve for chromosomal damage with respect to low- or 
      high-dose-rate gamma rays. Estimates of RBEmax values for mitotic spreads, which 
      ranged from near 0.7 to 11.1 for total exchanges, increased with LET, reaching a 
      maximum at about 150 keV/microm, and decreased with further increase in LET. RBEs 
      for complex aberrations are undefined due to the lack of an initial slope for 
      gamma rays. Additionally, the effect of mitotic delay on RBE values was 
      investigated by measuring chromosome aberrations in interphase after chemically 
      induced premature chromosome condensation (PCC), and values were up to threefold 
      higher than for metaphase analysis.
FAU - George, Kerry
AU  - George K
AD  - Wyle Laboratories, 1290 Hercules Drive, Houston, Texas 77058, USA. 
      Kerry.A.George1@jsc.nasa.gov
FAU - Durante, Marco
AU  - Durante M
FAU - Willingham, Veronica
AU  - Willingham V
FAU - Wu, Honglu
AU  - Wu H
FAU - Yang, Tracy C
AU  - Yang TC
FAU - Cucinotta, Francis A
AU  - Cucinotta FA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
SB  - IM
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human/*radiation effects/*ultrastructure
MH  - Dose-Response Relationship, Radiation
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase/radiation effects
MH  - *Linear Energy Transfer
MH  - Lymphocytes/*cytology/*radiation effects
MH  - Metaphase/radiation effects
MH  - Radiation Dosage
MH  - Relative Biological Effectiveness
OTO - NASA
OT  - NASA Center JSC
OT  - NASA Discipline Radiation Health
OT  - NASA Program Biomedical Research and Countermeasures
FIR - Cucinotta, F A
IR  - Cucinotta FA
IRAD- NASA JSC
EDAT- 2003/09/13 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/09/13 05:00
PHST- 2003/09/13 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/09/13 05:00 [entrez]
AID - RR3064 [pii]
AID - 10.1667/rr3064 [doi]
PST - ppublish
SO  - Radiat Res. 2003 Oct;160(4):425-35. doi: 10.1667/rr3064.