PMID- 1296936
OWN - NLM
STAT- MEDLINE
DCOM- 19930428
LR  - 20131121
IS  - 0253-8768 (Print)
IS  - 0253-8768 (Linking)
VI  - 10
IP  - 4
DP  - 1992 Dec
TI  - Effect of berberine on enterotoxin-induced intestinal fluid accumulation in rats.
PG  - 201-4
AB  - We have determined the effects of berberine (Berberis aristita) on intestinal 
      fluid accumulation due to enterotoxigenic E. coli (ETEC) heat-stable (ST) toxin 
      in suckling (24-days old) Wistar rats. Intestinal fluid accumulation occurred in 
      suckling Wistar rats by administration of culture filtrate containing 
      ST-producing ETEC in serial dilutions up to 1/8 dilution by oral or intragastric 
      route. When berberine (0.1 mg) and 1/8 dilution of ST-toxin were given together 
      by oral or intragastric injection, a significant (p < 0.01) reduction in fluid 
      accumulation was observed. Neither treatment with berberine orally before 
      intragastric injection of ST-toxin nor intragastric administration of berberine 
      after ST-toxin reduced the fluid accumulation due to ST-toxin.
FAU - Khin-Maung-U
AU  - Khin-Maung-U
AD  - Clinical Research Division, Department of Medical Research, Rangoon, Myanmar, 
      Burma.
FAU - Nwe-Nwe-Wai
AU  - Nwe-Nwe-Wai
LA  - eng
PT  - Journal Article
PL  - Bangladesh
TA  - J Diarrhoeal Dis Res
JT  - Journal of diarrhoeal diseases research
JID - 8402695
RN  - 0 (Bacterial Toxins)
RN  - 0 (Enterotoxins)
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (heat stable toxin (E coli))
RN  - 0I8Y3P32UF (Berberine)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Animals, Suckling
MH  - *Bacterial Toxins
MH  - Berberine/administration & dosage/*pharmacology
MH  - Body Water/drug effects
MH  - *Enterotoxins
MH  - Escherichia coli Proteins
MH  - Intestines/*drug effects/pathology
MH  - Rats
MH  - Rats, Wistar
EDAT- 1992/12/01 00:00
MHDA- 1992/12/01 00:01
CRDT- 1992/12/01 00:00
PHST- 1992/12/01 00:00 [pubmed]
PHST- 1992/12/01 00:01 [medline]
PHST- 1992/12/01 00:00 [entrez]
PST - ppublish
SO  - J Diarrhoeal Dis Res. 1992 Dec;10(4):201-4.