PMID- 12969506
OWN - NLM
STAT- MEDLINE
DCOM- 20040601
LR  - 20221207
IS  - 1471-2350 (Electronic)
IS  - 1471-2350 (Linking)
VI  - 4
DP  - 2003 Sep 12
TI  - Association of HLA class I with severe acute respiratory syndrome coronavirus 
      infection.
PG  - 9
AB  - BACKGROUND: The human leukocyte antigen (HLA) system is widely used as a strategy 
      in the search for the etiology of infectious diseases and autoimmune disorders. 
      During the Taiwan epidemic of severe acute respiratory syndrome (SARS), many 
      health care workers were infected. In an effort to establish a screening program 
      for high risk personal, the distribution of HLA class I and II alleles in case 
      and control groups was examined for the presence of an association to a genetic 
      susceptibly or resistance to SARS coronavirus infection. METHODS: HLA-class I and 
      II allele typing by PCR-SSOP was performed on 37 cases of probable SARS, 28 fever 
      patients excluded later as probable SARS, and 101 non-infected health care 
      workers who were exposed or possibly exposed to SARS coronavirus. An additional 
      control set of 190 normal healthy unrelated Taiwanese was also used in the 
      analysis. RESULTS: Woolf and Haldane Odds ratio (OR) and corrected P-value (Pc) 
      obtained from two tails Fisher exact test were used to show susceptibility of HLA 
      class I or class II alleles with coronavirus infection. At first, when analyzing 
      infected SARS patients and high risk health care workers groups, HLA-B*4601 (OR = 
      2.08, P = 0.04, Pc = n.s.) and HLA-B*5401 (OR = 5.44, P = 0.02, Pc = n.s.) 
      appeared as the most probable elements that may be favoring SARS coronavirus 
      infection. After selecting only a "severe cases" patient group from the infected 
      "probable SARS" patient group and comparing them with the high risk health care 
      workers group, the severity of SARS was shown to be significantly associated with 
      HLA-B*4601 (P = 0.0008 or Pc = 0.0279). CONCLUSIONS: Densely populated regions 
      with genetically related southern Asian populations appear to be more affected by 
      the spreading of SARS infection. Up until recently, no probable SARS patients 
      were reported among Taiwan indigenous peoples who are genetically distinct from 
      the Taiwanese general population, have no HLA-B* 4601 and have high frequency of 
      HLA-B* 1301. While increase of HLA-B* 4601 allele frequency was observed in the 
      "Probable SARS infected" patient group, a further significant increase of the 
      allele was seen in the "Severe cases" patient group. These results appeared to 
      indicate association of HLA-B* 4601 with the severity of SARS infection in Asian 
      populations. Independent studies are needed to test these results.
FAU - Lin, Marie
AU  - Lin M
AD  - Transfusion Medicine Laboratory, Mackay Memorial Hospital, Taipei, Taiwan. 
      marilin@ms2.mmh.org.tw
FAU - Tseng, Hsiang-Kuang
AU  - Tseng HK
FAU - Trejaut, Jean A
AU  - Trejaut JA
FAU - Lee, Hui-Lin
AU  - Lee HL
FAU - Loo, Jun-Hun
AU  - Loo JH
FAU - Chu, Chen-Chung
AU  - Chu CC
FAU - Chen, Pei-Jan
AU  - Chen PJ
FAU - Su, Ying-Wen
AU  - Su YW
FAU - Lim, Ken Hong
AU  - Lim KH
FAU - Tsai, Zen-Uong
AU  - Tsai ZU
FAU - Lin, Ruey-Yi
AU  - Lin RY
FAU - Lin, Ruey-Shiung
AU  - Lin RS
FAU - Huang, Chun-Hsiung
AU  - Huang CH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20030912
PL  - England
TA  - BMC Med Genet
JT  - BMC medical genetics
JID - 100968552
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*46:01 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Female
MH  - Gene Frequency
MH  - Genetic Testing/methods
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Testing/methods
MH  - Humans
MH  - Immunity, Innate/genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymerase Chain Reaction/methods
MH  - Severe acute respiratory syndrome-related coronavirus/immunology
MH  - Severe Acute Respiratory Syndrome/diagnosis/genetics/*immunology
MH  - Taiwan
PMC - PMC212558
EDAT- 2003/09/13 05:00
MHDA- 2004/06/02 05:00
PMCR- 2003/09/12
CRDT- 2003/09/13 05:00
PHST- 2003/06/26 00:00 [received]
PHST- 2003/09/12 00:00 [accepted]
PHST- 2003/09/13 05:00 [pubmed]
PHST- 2004/06/02 05:00 [medline]
PHST- 2003/09/13 05:00 [entrez]
PHST- 2003/09/12 00:00 [pmc-release]
AID - 1471-2350-4-9 [pii]
AID - 10.1186/1471-2350-4-9 [doi]
PST - epublish
SO  - BMC Med Genet. 2003 Sep 12;4:9. doi: 10.1186/1471-2350-4-9.