PMID- 12970761
OWN - NLM
STAT- MEDLINE
DCOM- 20031029
LR  - 20131121
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 4
IP  - 10
DP  - 2003 Oct
TI  - LAT regulates gammadelta T cell homeostasis and differentiation.
PG  - 999-1008
AB  - LAT (linker for activation of T cells) is essential for T cell receptor 
      signaling. Mice homozygous for a mutation of the three C-terminal LAT tyrosine 
      residues showed a block in alphabeta T cell development and a partially impaired 
      gammadelta T cell development. Without intentional immunization, they accumulated 
      gammadelta T cells in the spleen and lymph nodes that chronically produced T 
      helper type 2 cytokines in large amounts, and caused the maturation of plasma 
      cells secreting immunoglobulin E (IgE) and IgG1. These effects are very similar 
      to that triggered in the alphabeta lineage by a mutation involving a distinct LAT 
      tyrosine. Thus, LAT is an essential regulator of T cell homeostasis and terminal 
      differentiation.
FAU - Nunez-Cruz, Selene
AU  - Nunez-Cruz S
AD  - Centre d'Immunologie de Marseille-Luminy, Institut National de la Sante et de la 
      Recherche Medicale-Centre National de la Recherche Scientifique-Universite de la 
      Mediterranee, Parc Scientifique de Luminy, Case 906, 13288 Marseille Cedex 9, 
      France.
FAU - Aguado, Enrique
AU  - Aguado E
FAU - Richelme, Sylvie
AU  - Richelme S
FAU - Chetaille, Bruno
AU  - Chetaille B
FAU - Mura, Anne-Marie
AU  - Mura AM
FAU - Richelme, Mireille
AU  - Richelme M
FAU - Pouyet, Laurent
AU  - Pouyet L
FAU - Jouvin-Marche, Evelyne
AU  - Jouvin-Marche E
FAU - Xerri, Luc
AU  - Xerri L
FAU - Malissen, Bernard
AU  - Malissen B
FAU - Malissen, Marie
AU  - Malissen M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20030914
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Lat protein, mouse)
RN  - 0 (Membrane Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
RN  - 42HK56048U (Tyrosine)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Base Sequence
MH  - Carrier Proteins/genetics/*immunology
MH  - Cell Differentiation/genetics/immunology
MH  - Cytokines/immunology
MH  - Flow Cytometry
MH  - Homeostasis/immunology
MH  - Immunohistochemistry
MH  - Lymphocyte Activation/immunology
MH  - *Membrane Proteins
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Knockout
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Phenotype
MH  - Phosphoproteins/genetics/*immunology
MH  - Receptors, Antigen, T-Cell, gamma-delta/genetics/*immunology
MH  - Signal Transduction/genetics/immunology
MH  - Spleen/immunology
MH  - T-Lymphocytes/*immunology
MH  - Th2 Cells/immunology/metabolism
MH  - Tyrosine/genetics
EDAT- 2003/09/13 05:00
MHDA- 2003/10/30 05:00
CRDT- 2003/09/13 05:00
PHST- 2003/06/16 00:00 [received]
PHST- 2003/08/14 00:00 [accepted]
PHST- 2003/09/13 05:00 [pubmed]
PHST- 2003/10/30 05:00 [medline]
PHST- 2003/09/13 05:00 [entrez]
AID - ni977 [pii]
AID - 10.1038/ni977 [doi]
PST - ppublish
SO  - Nat Immunol. 2003 Oct;4(10):999-1008. doi: 10.1038/ni977. Epub 2003 Sep 14.