PMID- 12971404
OWN - NASA
STAT- MEDLINE
DCOM- 20031106
LR  - 20190916
IS  - 0273-1177 (Print)
IS  - 0273-1177 (Linking)
VI  - 31
IP  - 6
DP  - 2003
TI  - Biological dosimetry in Russian and Italian astronauts.
PG  - 1495-503
AB  - Large uncertainties are associated with estimates of equivalent dose and cancer 
      risk for crews of long-term space missions. Biological dosimetry in astronauts is 
      emerging as a useful technique to compare predictions based on quality factors 
      and risk coefficients with actual measurements of biological damage in-flight. In 
      the present study, chromosomal aberrations were analyzed in one Italian and eight 
      Russian cosmonauts following missions of different duration on the MIR and the 
      international space station (ISS). We used the technique of fluorescence in situ 
      hybridization (FISH) to visualize translocations in chromosomes 1 and 2. In some 
      cases, an increase in chromosome damage was observed after flight, but no 
      correlation could be found between chromosome damage and flight history, in terms 
      of number of flights at the time of sampling, duration in space and 
      extra-vehicular activity. Blood samples from one of the cosmonauts were exposed 
      in vitro to 6 MeV X-rays both before and after the flight. An enhancement in 
      radiosensitivity induced by the spaceflight was observed.
CI  - c2003 COSPAR. Published by Elsevier Science Ltd. All rights reserved.
FAU - Greco, O
AU  - Greco O
AD  - Radiation Oncology Department, Karmanos Cancer Institute, Detroit, MI 48201-2013, 
      USA.
FAU - Durante, M
AU  - Durante M
FAU - Gialanella, G
AU  - Gialanella G
FAU - Grossi, G
AU  - Grossi G
FAU - Pugliese, M
AU  - Pugliese M
FAU - Scampoli, P
AU  - Scampoli P
FAU - Snigiryova, G
AU  - Snigiryova G
FAU - Obe, G
AU  - Obe G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Adv Space Res
JT  - Advances in space research : the official journal of the Committee on Space 
      Research (COSPAR)
JID - 9878935
MH  - *Astronauts
MH  - Chromosome Aberrations/classification/*statistics & numerical data
MH  - *Cosmic Radiation
MH  - Dose-Response Relationship, Radiation
MH  - Extravehicular Activity
MH  - Humans
MH  - Italy
MH  - Lymphocytes/cytology/*radiation effects
MH  - Neoplasms, Radiation-Induced/prevention & control
MH  - *Occupational Exposure
MH  - Radiation Dosage
MH  - Risk Assessment
MH  - Russia
MH  - *Space Flight
OID - NASA: 00029717
SFM - Flight Experiment
SFM - ISS Project
SFM - Mir Project
SFM - long duration
SFM - manned
GN  - NASA: Grant numbers: 50WB0030, 99-00214.
EDAT- 2003/09/16 05:00
MHDA- 2003/11/07 05:00
CRDT- 2003/09/16 05:00
PHST- 2003/09/16 05:00 [pubmed]
PHST- 2003/11/07 05:00 [medline]
PHST- 2003/09/16 05:00 [entrez]
AID - 10.1016/s0273-1177(03)00087-5 [doi]
PST - ppublish
SO  - Adv Space Res. 2003;31(6):1495-503. doi: 10.1016/s0273-1177(03)00087-5.