PMID- 12971897
OWN - NLM
STAT- MEDLINE
DCOM- 20031014
LR  - 20190823
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 39
IP  - 6
DP  - 2003 Sep 11
TI  - Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP 
      at hippocampal CA1-CA3 synapses.
PG  - 975-90
AB  - Brain-derived neurotrophic factor (BDNF) has been implicated in several forms of 
      long-term potentiation (LTP) at different hippocampal synapses. Using two-photon 
      imaging of FM 1-43, a fluorescent marker of synaptic vesicle cycling, we find 
      that BDNF is selectively required for those forms of LTP at Schaffer collateral 
      synapses that recruit a presynaptic component of expression. BDNF-dependent forms 
      of LTP also require activation of L-type voltage-gated calcium channels. One form 
      of LTP with presynaptic expression, theta burst LTP, is thought to be of 
      particular behavioral importance. Using restricted genetic deletion to 
      selectively disrupt BDNF production in either the entire forebrain (CA3 and CA1) 
      or in only the postsynaptic CA1 neuron, we localize the source of BDNF required 
      for LTP to presynaptic neurons. These results suggest that long-term synaptic 
      plasticity has distinct presynaptic and postsynaptic modules. Release of BDNF 
      from CA3 neurons is required to recruit the presynaptic, but not postsynaptic, 
      module of plasticity.
FAU - Zakharenko, Stanislav S
AU  - Zakharenko SS
AD  - Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, 
      New York, NY 10032, USA.
FAU - Patterson, Susan L
AU  - Patterson SL
FAU - Dragatsis, Ioannis
AU  - Dragatsis I
FAU - Zeitlin, Scott O
AU  - Zeitlin SO
FAU - Siegelbaum, Steven A
AU  - Siegelbaum SA
FAU - Kandel, Eric R
AU  - Kandel ER
FAU - Morozov, Alexei
AU  - Morozov A
LA  - eng
GR  - MH50733/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/*deficiency/genetics/*physiology
MH  - Female
MH  - Gene Expression Regulation/physiology
MH  - Hippocampus/drug effects/*metabolism
MH  - Long-Term Potentiation/drug effects/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Neurons/drug effects/metabolism
MH  - Presynaptic Terminals/drug effects/*metabolism
MH  - Synapses/drug effects/metabolism
EDAT- 2003/09/16 05:00
MHDA- 2003/10/15 05:00
CRDT- 2003/09/16 05:00
PHST- 2003/09/16 05:00 [pubmed]
PHST- 2003/10/15 05:00 [medline]
PHST- 2003/09/16 05:00 [entrez]
AID - S0896627303005439 [pii]
AID - 10.1016/s0896-6273(03)00543-9 [doi]
PST - ppublish
SO  - Neuron. 2003 Sep 11;39(6):975-90. doi: 10.1016/s0896-6273(03)00543-9.