PMID- 12971970
OWN - NLM
STAT- MEDLINE
DCOM- 20040713
LR  - 20190817
IS  - 0168-8278 (Print)
IS  - 0168-8278 (Linking)
VI  - 39
IP  - 4
DP  - 2003 Oct
TI  - Human leukocyte antigen-G (HLA-G) expression in biliary epithelial cells is 
      associated with allograft acceptance in liver-kidney transplantation.
PG  - 587-94
AB  - BACKGROUND/AIMS: Liver allograft is known to protect simultaneously transplanted 
      organs from acute rejection. We have reported that only 6% of combined 
      liver-kidney recipients, versus 32.5% of kidney recipients, develop kidney graft 
      acute rejection. Release of soluble human leukocyte antigen (HLA) molecules by 
      the liver has been proposed as a possible tolerogenic mechanism involved in the 
      better acceptance of double transplants. The HLA-G molecule is acknowledged to 
      possess tolerogenic properties. METHODS: We investigated the involvement of HLA-G 
      in allogeneic transplant acceptance by analyzing its expression in kidney and 
      liver biopsies of 40 combined transplanted patients. RESULTS: We demonstrate the 
      presence of HLA-G in 14 out of 40 liver and five out of nine kidney transplants 
      biopsies. HLA-G is expressed de novo by cells that are otherwise frequently 
      susceptible target cells of acute rejection, i.e. liver biliary and renal tubular 
      epithelial cells. We show a significant association between HLA-G expression in 
      liver biliary epithelial cells and the absence of liver graft rejection. No acute 
      or chronic rejection of the kidney graft was observed in patients in whom HLA-G 
      was expressed in the liver graft. CONCLUSIONS: HLA-G expression in the liver 
      allograft is associated with a lower frequency of hepatic and renal acute 
      rejection and may be involved in the acceptance of simultaneously transplanted 
      organs.
FAU - Creput, Caroline
AU  - Creput C
AD  - Hemato-immunology Research Institute, CEA Laboratory, Direction des Sciences du 
      Vivant, Departement de Recherche Medicale, Commissariat a l'Energie Atomique, 
      Institut Universitaire d'Hematologie, Saint-Louis Hospital, 75010 Paris Cedex 10, 
      France.
FAU - Durrbach, Antoine
AU  - Durrbach A
FAU - Menier, Catherine
AU  - Menier C
FAU - Guettier, Catherine
AU  - Guettier C
FAU - Samuel, Didier
AU  - Samuel D
FAU - Dausset, Jean
AU  - Dausset J
FAU - Charpentier, Bernard
AU  - Charpentier B
FAU - Carosella, Edgardo D
AU  - Carosella ED
FAU - Rouas-Freiss, Nathalie
AU  - Rouas-Freiss N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Hepatol
JT  - Journal of hepatology
JID - 8503886
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Biliary Tract/cytology/*metabolism
MH  - Biopsy
MH  - Epithelial Cells/metabolism
MH  - Female
MH  - Graft Rejection/prevention & control
MH  - *Graft Survival
MH  - HLA Antigens/*metabolism
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*metabolism
MH  - Humans
MH  - *Immune Tolerance
MH  - Immunohistochemistry
MH  - Kidney/metabolism/pathology
MH  - Kidney Transplantation/*immunology
MH  - Liver/metabolism/pathology
MH  - Liver Transplantation/*immunology
MH  - Male
MH  - Middle Aged
MH  - Transplantation, Homologous
EDAT- 2003/09/16 05:00
MHDA- 2004/07/14 05:00
CRDT- 2003/09/16 05:00
PHST- 2003/09/16 05:00 [pubmed]
PHST- 2004/07/14 05:00 [medline]
PHST- 2003/09/16 05:00 [entrez]
AID - S0168827803003544 [pii]
AID - 10.1016/s0168-8278(03)00354-4 [doi]
PST - ppublish
SO  - J Hepatol. 2003 Oct;39(4):587-94. doi: 10.1016/s0168-8278(03)00354-4.