PMID- 12972167
OWN - NLM
STAT- MEDLINE
DCOM- 20031106
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 350
IP  - 2
DP  - 2003 Oct 23
TI  - The effect of 3,4-methylenedioxymethamphetamine ('Ecstasy') on serotonergic 
      regulation of the mammalian circadian clock mechanism in rats: the role of 
      dopamine and hyperthermia.
PG  - 117-21
AB  - The recreational drug 3,4-methylenedioxymethamphetamine (MDMA) is known to be a 
      neurotoxin for serotonergic axons ascending from the raphe nucleus including 
      those which terminate on neurons of the suprachiasmatic nuclei (SCN) of the 
      hypothalamus, the putative mammalian circadian clock. Since dopamine release has 
      been implicated in the serotonergic neurotoxicity, we examined the effects of the 
      dopamine synthesis inhibitor alpha-methyl-p-tyrosine (AMPT) and the D2 receptor 
      antagonist haloperidol (HAL) on the long-term effect of MDMA on serotonergic 
      regulation of the SCN neuronal firing rhythm. Co-administration of AMPT or HAL 
      with MDMA eliminated the acute hyperthermic response but had no effect on the 
      MDMA-induced phase shift in the firing rhythm of SCN neurons to the selective 
      5-HT1A receptor agonist, 8-hydroxy-2-(dipropylamino)-tetralin. It is concluded 
      that neither dopamine metabolism nor hyperthermia account for the altered 
      serotonergic function in the SCN produced by MDMA. Toxic free radical production 
      following MDMA metabolism may be responsible.
FAU - Dafters, Richard I
AU  - Dafters RI
AD  - Psychology Department, 58 Hillhead Street, Glasgow University, Glasgow, G12 8QB, 
      UK. r.dafters@psy.gla.ac.uk
FAU - Biello, Stephany M
AU  - Biello SM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Body Temperature/drug effects/physiology
MH  - Circadian Rhythm/*drug effects/physiology
MH  - Dopamine/*metabolism
MH  - Dopamine Antagonists/pharmacology
MH  - Fever/chemically induced/*metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology/toxicity
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/*metabolism
MH  - Serotonin Receptor Agonists/pharmacology
MH  - Suprachiasmatic Nucleus/drug effects/metabolism
EDAT- 2003/09/16 05:00
MHDA- 2003/11/07 05:00
CRDT- 2003/09/16 05:00
PHST- 2003/09/16 05:00 [pubmed]
PHST- 2003/11/07 05:00 [medline]
PHST- 2003/09/16 05:00 [entrez]
AID - S0304394003008553 [pii]
AID - 10.1016/s0304-3940(03)00855-3 [doi]
PST - ppublish
SO  - Neurosci Lett. 2003 Oct 23;350(2):117-21. doi: 10.1016/s0304-3940(03)00855-3.