PMID- 12974988
OWN - NLM
STAT- MEDLINE
DCOM- 20050718
LR  - 20161020
IS  - 1461-1457 (Print)
IS  - 1461-1457 (Linking)
VI  - 6
IP  - 3
DP  - 2003 Sep
TI  - Lithium treatment alters brain concentrations of nerve growth factor, 
      brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor 
      in a rat model of depression.
PG  - 225-31
AB  - Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and glial 
      cell line-derived neurotrophic factor (GDNF) are proteins involved in neuronal 
      survival and plasticity of dopaminergic, cholinergic and serotonergic neurons in 
      the central nervous system. Since decreased size and impaired function of some 
      neuronal populations may be relevant in depression it has been hypothesized that 
      these molecules may have a functional role in the pathophysiology as well as 
      treatment of depression. Using an animal model of depression, the Flinders 
      Sensitive Line (FSL) rats and their controls, the Flinders Resistant Line (FRL), 
      we investigated the effects of chronic lithium treatment on brain NGF, BDNF and 
      GDNF. Lithium was administered as food supplementation during 6 wk. NGF, BDNF and 
      GDNF measurements were performed by enzyme-linked immunosorbent assay (ELISA). 
      Lithium altered the brain concentrations of neurotrophic factors in the 
      hippocampus, frontal cortex, occipital cortex and striatum. Moreover, the changes 
      were different in the two rat strains. Our data support the notion that 
      neurotrophic factors play a role in depression and in the mechanism of the action 
      of lithium.
FAU - Angelucci, Francesco
AU  - Angelucci F
AD  - Karolinska Institutet, Department of Physiology and Pharmacology, Division of 
      Pharmacology, Stockholm, Sweden.
FAU - Aloe, Luigi
AU  - Aloe L
FAU - Jimenez-Vasquez, Patricia
AU  - Jimenez-Vasquez P
FAU - Mathe, Aleksander A
AU  - Mathe AA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Antimanic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Gdnf protein, rat)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 9FN79X2M3F (Lithium)
SB  - IM
MH  - Animals
MH  - Antimanic Agents/*pharmacology/therapeutic use
MH  - Brain Chemistry/*drug effects
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depression/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - Lithium/*pharmacology/therapeutic use
MH  - Nerve Growth Factors/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 2003/09/17 05:00
MHDA- 2005/07/19 09:00
CRDT- 2003/09/17 05:00
PHST- 2003/02/27 00:00 [revised]
PHST- 2003/09/17 05:00 [pubmed]
PHST- 2005/07/19 09:00 [medline]
PHST- 2003/09/17 05:00 [entrez]
AID - S1461145703003468 [pii]
AID - 10.1017/S1461145703003468 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2003 Sep;6(3):225-31. doi: 10.1017/S1461145703003468.