PMID- 1305693
OWN - NLM
STAT- MEDLINE
DCOM- 19930722
LR  - 20220331
IS  - 0733-1959 (Print)
IS  - 0733-1959 (Linking)
VI  - 16I
DP  - 1992
TI  - Chromosome changes in early bladder neoplasms.
PG  - 76-9
AB  - There are few cytogenetic studies of early (non-invasive) bladder cancer, 
      particularly in situ carcinoma, due to technical difficulties in examining such 
      lesions. The best approach is to extrapolate from chromosomal changes in more 
      advanced cancers. Although no specific chromosomal changes have been established 
      in either early or fully developed bladder cancers, certain recurrent anomalies 
      have been encountered. Anomalies such as +1, +7, -9, 5q- or i(5p), 11p- and -Y 
      appear to constitute part of the multistep carcinogenetic process by which 
      clinically and pathologically recognizable bladder cancers develop. Since loss of 
      part or all of chromosome 9 (-9) is a common and early cytogenetic event in 
      bladder cancer, the detection of -9 in bladder washings or urine by fluorescence 
      in situ hybridization (FISH) may be a promising test for early or recurrent 
      bladder cancer. Although less frequent than -9, trisomy 7 (+7) is common enough 
      to serve a similar purpose. In contrast, loss of the Y chromosome may indicate an 
      advanced stage of bladder cancer. Thus, FISH studies utilizing probes for 
      chromosomes 7, 9, and Y should yield cogent information to identify early bladder 
      cancer. Cytogenetic (including FISH) studies combined with certain molecular 
      approaches (e.g., p53 mutations detected immunochemically) may not only serve to 
      differentiate early cancer from benign tumors or conditions, but may also help 
      establish cancer stage. This would supply data of considerable usefulness to the 
      clinician and pathologist.
FAU - Sandberg, A A
AU  - Sandberg AA
AD  - Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Cell Biochem Suppl
JT  - Journal of cellular biochemistry. Supplement
JID - 8207539
SB  - IM
MH  - Chromosome Aberrations/*pathology
MH  - Chromosome Disorders
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Neoplasm Invasiveness
MH  - Time Factors
MH  - Urinary Bladder Neoplasms/*genetics/pathology
RF  - 12
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1002/jcb.240501317 [doi]
PST - ppublish
SO  - J Cell Biochem Suppl. 1992;16I:76-9. doi: 10.1002/jcb.240501317.