PMID- 1309393
OWN - NLM
STAT- MEDLINE
DCOM- 19920130
LR  - 20041117
IS  - 0031-4005 (Print)
IS  - 0031-4005 (Linking)
VI  - 89
IP  - 1
DP  - 1992 Jan
TI  - Serology versus clinical signs or symptoms and main laboratory findings in the 
      diagnosis of exanthema subitum (roseola infantum).
PG  - 103-6
AB  - Twenty-five patients with clinical exanthema subitum (roseola infantum) were 
      enrolled into a study, where acute-phase and convalescent sera were examined for 
      antibodies to human herpesvirus 6 (HHV-6), several other viruses, and other 
      microbes. In addition, an acute-phase fecal specimen was examined for viruses by 
      electron microscopy. Confirmative or suggestive serologic evidence for recent 
      HHV-6 infection was obtained in 23 (92%) cases. Conversion to HHV-6 was found in 
      19 (76%), a diagnostic (greater than or equal to 4-fold) titer rise in 2, a 
      twofold titer rise in 1, and a stable relatively high titer in 1 of the patients; 
      only 2 (8%) individuals remained negative. The other microbial assays produced 
      only two slight mycoplasma antibody rises and one rotavirus identification in the 
      fecal specimen. It is concluded that if the clinical diagnosis of exanthema 
      subitum is deemed doubtful, HHV-6 infection is verifiable in about 75% of the 
      cases by serology.
FAU - Linnavuori, K
AU  - Linnavuori K
AD  - Department of Virology, University of Helsinki, Finland.
FAU - Peltola, H
AU  - Peltola H
FAU - Hovi, T
AU  - Hovi T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Antibodies, Viral/analysis
MH  - Exanthema Subitum/diagnosis/*microbiology
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Herpesviridae Infections/*diagnosis
MH  - Herpesvirus 6, Human/isolation & purification
MH  - Humans
MH  - Infant
MH  - Male
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Pediatrics. 1992 Jan;89(1):103-6.