PMID- 1311674
OWN - NLM
STAT- MEDLINE
DCOM- 19920409
LR  - 20191021
IS  - 0893-6692 (Print)
IS  - 0893-6692 (Linking)
VI  - 19
IP  - 2
DP  - 1992
TI  - Nitrobenzo[a]pyrene-induced DNA amplification in SV40-transformed Chinese hamster 
      embryo cells.
PG  - 156-60
AB  - Nitrobenzo[a]pyrenes (NBaPs) are ubiquitous environmental pollutants that produce 
      mutations in Salmonella typhimurium and Chinese hamster ovary cells. In this 
      study, 1-, 3-, and 6-NBaP induced amplification of SV40 DNA sequences in an 
      SV40-transformed Chinese hamster embryo cell line which is sensitive to DNA 
      amplification by various known carcinogens. Of the three isomers, 3-NBaP produced 
      the highest level of gene amplification, which was 4.8 relative to untreated 
      controls at a dose of 5 micrograms/ml. Considering the relationship between gene 
      amplification and tumorigenesis, it seems prudent to carry out a more exhaustive 
      analysis of the carcinogenic potential of these agents.
FAU - Neft, R E
AU  - Neft RE
AD  - Division of Genetic Toxicology, Food and Drug Administration, National Center for 
      Toxicological Research, Jefferson, AR 72079-9502.
FAU - Roe, A L
AU  - Roe AL
FAU - Schol, H M
AU  - Schol HM
FAU - Fu, P P
AU  - Fu PP
FAU - Mittelstaedt, R A
AU  - Mittelstaedt RA
FAU - Casciano, D A
AU  - Casciano DA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Environ Mol Mutagen
JT  - Environmental and molecular mutagenesis
JID - 8800109
RN  - 0 (Benzopyrenes)
RN  - 0 (DNA, Viral)
RN  - 0 (Mutagens)
SB  - IM
MH  - Animals
MH  - Benzopyrenes/*toxicity
MH  - Cell Line, Transformed
MH  - Cell Transformation, Viral/*drug effects
MH  - Cricetinae
MH  - Cricetulus
MH  - DNA, Viral/biosynthesis/*drug effects
MH  - Embryo, Mammalian/cytology
MH  - Gene Amplification/*drug effects
MH  - *Mutagens
MH  - Simian virus 40/*genetics/physiology
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1002/em.2850190210 [doi]
PST - ppublish
SO  - Environ Mol Mutagen. 1992;19(2):156-60. doi: 10.1002/em.2850190210.