PMID- 1312256
OWN - NLM
STAT- MEDLINE
DCOM- 19920416
LR  - 20220330
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 255
IP  - 5047
DP  - 1992 Feb 21
TI  - The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor.
PG  - 989-91
AB  - The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine 
      kinase family. Expression of flt complementary DNA in COS cells conferred 
      specific, high-affinity binding of vascular endothelial growth factor, also known 
      as vascular permeability factor (VEGF-VPF), a factor that induces vascular 
      permeability when injected in the guinea pig skin and stimulates endothelial cell 
      proliferation. Expression of Flt in Xenopus laevis oocytes caused the oocytes to 
      release calcium in response to VEGF-VPF. These findings show that flt encodes a 
      receptor for VEGF-VPF.
FAU - de Vries, C
AU  - de Vries C
AD  - Department of Medicine, University of California, San Francisco 94143.
FAU - Escobedo, J A
AU  - Escobedo JA
FAU - Ueno, H
AU  - Ueno H
FAU - Houck, K
AU  - Houck K
FAU - Ferrara, N
AU  - Ferrara N
FAU - Williams, L T
AU  - Williams LT
LA  - eng
GR  - P01 HL-43821/HL/NHLBI NIH HHS/United States
GR  - R01 HL-32898/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Cross-Linking Reagents)
RN  - 0 (Endothelial Growth Factors)
RN  - 0 (Lymphokines)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factors)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
SB  - IM
MH  - Animals
MH  - Cloning, Molecular
MH  - Cross-Linking Reagents
MH  - Endothelial Growth Factors/*physiology
MH  - Enzyme Activation
MH  - Humans
MH  - In Vitro Techniques
MH  - Lymphokines/*physiology
MH  - Proto-Oncogene Proteins/genetics/*physiology
MH  - Receptors, Cell Surface/*genetics
MH  - Signal Transduction
MH  - Transfection
MH  - Vascular Endothelial Growth Factor A
MH  - Vascular Endothelial Growth Factor Receptor-1
MH  - Vascular Endothelial Growth Factors
MH  - Xenopus laevis
EDAT- 1992/02/21 00:00
MHDA- 1992/02/21 00:01
CRDT- 1992/02/21 00:00
PHST- 1992/02/21 00:00 [pubmed]
PHST- 1992/02/21 00:01 [medline]
PHST- 1992/02/21 00:00 [entrez]
AID - 10.1126/science.1312256 [doi]
PST - ppublish
SO  - Science. 1992 Feb 21;255(5047):989-91. doi: 10.1126/science.1312256.