PMID- 1312639
OWN - NLM
STAT- MEDLINE
DCOM- 19920417
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 66
IP  - 4
DP  - 1992 Apr
TI  - Characterization of dexamethasone-induced reactivation of latent bovine 
      herpesvirus 1.
PG  - 2484-90
AB  - Synchronous reactivation of bovine herpesvirus type 1 in all latently infected 
      rabbits was achieved following a single intravenous dose of dexamethasone. 
      Reactivated latent virus was first present in ocular secretions between 48 and 72 
      h post-dexamethasone treatment (PT). Cell-free infectious virus, 
      viral-antigen-containing neurons, and pathologic changes were detectable in 
      trigeminal ganglia (TG) by 48 h PT. A shift from the viral transcriptional 
      pattern characteristic of the latent state (latency-related RNA [LR RNA]) to one 
      typical of that seen during acute infection was detected in a small number of 
      neurons in latently infected TG between 15 and 18 h PT, with viral DNA first 
      detectable by in situ hybridization at 18 to 21 h PT. The number of LR 
      RNA-containing neurons in latently infected TG decreased significantly at 24 and 
      48 h PT but returned to near-normal levels by 72 h PT. Correlation of this 
      decrease with viral reactivation suggests that altered regulation of LR RNA 
      transcription is a significant event in the process of viral reactivation.
FAU - Rock, D
AU  - Rock D
AD  - Department of Veterinary Science, University of Nebraska, Lincoln 68583.
FAU - Lokensgard, J
AU  - Lokensgard J
FAU - Lewis, T
AU  - Lewis T
FAU - Kutish, G
AU  - Kutish G
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Dexamethasone/*pharmacology
MH  - Genome, Viral
MH  - Herpesvirus 1, Bovine/genetics/*growth & development
MH  - Infectious Bovine Rhinotracheitis/microbiology
MH  - Rabbits
MH  - Restriction Mapping
MH  - Transcription, Genetic
MH  - Virus Activation/*drug effects
PMC - PMC289044
EDAT- 1992/04/01 00:00
MHDA- 1992/04/01 00:01
PMCR- 1992/04/01
CRDT- 1992/04/01 00:00
PHST- 1992/04/01 00:00 [pubmed]
PHST- 1992/04/01 00:01 [medline]
PHST- 1992/04/01 00:00 [entrez]
PHST- 1992/04/01 00:00 [pmc-release]
AID - 10.1128/JVI.66.4.2484-2490.1992 [doi]
PST - ppublish
SO  - J Virol. 1992 Apr;66(4):2484-90. doi: 10.1128/JVI.66.4.2484-2490.1992.