PMID- 1314074
OWN - NLM
STAT- MEDLINE
DCOM- 19920518
LR  - 20190827
IS  - 0960-0760 (Print)
IS  - 0960-0760 (Linking)
VI  - 41
IP  - 3-8
DP  - 1992 Mar
TI  - Transcriptional control by steroid hormones.
PG  - 241-8
AB  - Gene regulation by steroid hormones leads to induction or repression of 
      particular sets of genes. These effects are mediated by intracellular hormone 
      receptors that, in the unliganded state, are maintained in an inactive form by 
      unknown mechanisms possibly involving association with other cellular proteins. 
      Induction of the mouse mammary tumor virus (MMTV) requires binding of the hormone 
      receptor to a complex hormone-responsive element (HRE) located between 75 and 190 
      bp upstream from the start of transcription. The interaction of several receptor 
      molecules with the four receptor binding sites in the HRE is highly cooperative 
      on circular DNA molecules and each individual site is needed for optimal 
      induction. In chromatin the HRE is precisely organized in phased nucleosomes. 
      Following hormone treatment and receptor binding, changes in chromatin structure 
      are detected that correlate with binding of transcription factors, including 
      nuclear factor I, to the MMTV promoter. However, though nuclear factor I acts as 
      a basal transcription factor on the MMTV promoter it does not cooperate with the 
      hormone receptors in terms of binding to free DNA, and mutation of the nuclear 
      factor I binding site does not eliminate hormonal stimulation. This residual 
      induction is mediated by octamer motifs, upstream of the TATA box, that bind the 
      ubiquitous transcription factor OTF-1. Mutation of these octamer motifs does not 
      influence basal transcription in vitro, but completely abolishes the stimulatory 
      effect of progesterone receptor.
FAU - Truss, M
AU  - Truss M
AD  - Institut fur Molekularbiologie und Tumorforschung, Marburg, Fed. Rep. Germany.
FAU - Chalepakis, G
AU  - Chalepakis G
FAU - Pina, B
AU  - Pina B
FAU - Barettino, D
AU  - Barettino D
FAU - Bruggemeier, U
AU  - Bruggemeier U
FAU - Kalff, M
AU  - Kalff M
FAU - Slater, E P
AU  - Slater EP
FAU - Beato, M
AU  - Beato M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Steroid Biochem Mol Biol
JT  - The Journal of steroid biochemistry and molecular biology
JID - 9015483
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Hormones)
RN  - 0 (Receptors, Steroid)
RN  - 0 (Steroids)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - DNA-Binding Proteins/*metabolism
MH  - *Gene Expression Regulation
MH  - Hormones/*pharmacology
MH  - Humans
MH  - Mammary Tumor Virus, Mouse/genetics
MH  - Models, Structural
MH  - Molecular Sequence Data
MH  - Nucleic Acid Conformation
MH  - Protein Conformation
MH  - Receptors, Steroid/*metabolism
MH  - *Regulatory Sequences, Nucleic Acid
MH  - Steroids/*pharmacology
MH  - *Transcription, Genetic/drug effects
RF  - 33
EDAT- 1992/03/01 00:00
MHDA- 1992/03/01 00:01
CRDT- 1992/03/01 00:00
PHST- 1992/03/01 00:00 [pubmed]
PHST- 1992/03/01 00:01 [medline]
PHST- 1992/03/01 00:00 [entrez]
AID - 10.1016/0960-0760(92)90350-r [doi]
PST - ppublish
SO  - J Steroid Biochem Mol Biol. 1992 Mar;41(3-8):241-8. doi: 
      10.1016/0960-0760(92)90350-r.