PMID- 1315900
OWN - NLM
STAT- MEDLINE
DCOM- 19920609
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 50
IP  - 21
DP  - 1992
TI  - Antipyretic effect of central arginine8-vasopressin treatment: V1 receptors 
      specifically involved?
PG  - 1625-30
AB  - Intracerebroventricular (i.c.v.) administration of the neurohypophyseal 
      neuropeptide arginine8-vasopressin (AVP) results in a dose-dependent attenuation 
      of endotoxin-induced fever (EIF) in rats. Specific antagonists of the 
      neuropeptided(CH2)5[Tyr(Me)2]AVP for V1 receptors, d(CH2)5[dlle2lle4]AVP for the 
      V2 receptors and Des-Gly,NH2d(CH2)5[Tyr)Me2)Thr4Orn8]vasotocin, an antagonist of 
      the oxytocin receptors (AOXT), failed to modify EIF when administered i.c.v. 
      Relatively high doses (100 ng) of all three peptide antagonists effectively 
      blocked the antipyretic effect of AVP. Administered in smaller doses (10 or 30 
      ng), however, a more specific interaction was observed, i.e. the V1 antagonist 
      being the only effective compound in preventing the effect of AVP. Although the 
      data indicate that peptide-antagonist interactions should be interpreted 
      carefully, the present experiments confirm previous observations on the 
      involvement of V1-type receptors in the antipyretic action of AVP and suggest 
      additional interactions with V2 vasopressinergic and oxytocinergic receptors.
FAU - Kovacs, G L
AU  - Kovacs GL
AD  - Rudolf Magnus Institute for Pharmacology, University of Utrecht, The Netherlands.
FAU - Baars, A M
AU  - Baars AM
FAU - De Wied, D
AU  - De Wied D
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Endotoxins)
RN  - 0 (Receptors, Angiotensin)
RN  - 0 (Receptors, Oxytocin)
RN  - 0 (Receptors, Vasopressin)
RN  - 11000-17-2 (Vasopressins)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 50-56-6 (Oxytocin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Arginine Vasopressin/*pharmacology
MH  - Endotoxins/*pharmacology
MH  - *Hyperthermia, Induced
MH  - Male
MH  - Oxytocin/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Angiotensin/*drug effects
MH  - Receptors, Oxytocin
MH  - Receptors, Vasopressin
MH  - Vasopressins/metabolism
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 0024-3205(92)90448-X [pii]
AID - 10.1016/0024-3205(92)90448-x [doi]
PST - ppublish
SO  - Life Sci. 1992;50(21):1625-30. doi: 10.1016/0024-3205(92)90448-x.