PMID- 1315923
OWN - NLM
STAT- MEDLINE
DCOM- 19920610
LR  - 20200304
IS  - 0300-8177 (Print)
IS  - 0300-8177 (Linking)
VI  - 110
IP  - 1
DP  - 1992 Mar 4
TI  - The nerve growth factor receptor: a multicomponent system that mediates the 
      actions of the neurotrophin family of proteins.
PG  - 1-15
AB  - Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and 
      neurotrophin 3 (NT-3) are members of a family of structurally related proteins 
      termed neurotrophins that promote the growth and survival of neurons in the 
      central and peripheral nervous systems. Each of these proteins bind to at least 
      two membrane receptors. One is the low affinity nerve growth factor receptor 
      (p75), which binds each member of the neurotrophin family. The other is one of a 
      family of tyrosine kinase receptors--trkA binds only NGF, the related trkB 
      receptor binds BDNF and NT-3, and trkC binds NT-3 alone. This article reviews 
      kinetic and biochemical information on p75 and its relationship to the trk gene 
      products.
FAU - Barker, P A
AU  - Barker PA
AD  - Department of Anatomy and Cell Biology, University of Alberta, Edmonton, Canada.
FAU - Murphy, R A
AU  - Murphy RA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Nerve Growth Factor)
SB  - IM
GS  - trk
MH  - Animals
MH  - Antibodies, Monoclonal
MH  - Humans
MH  - Nerve Growth Factors/*physiology
MH  - Proto-Oncogenes/physiology
MH  - Receptors, Cell Surface/chemistry/metabolism/*physiology
MH  - Receptors, Nerve Growth Factor
RF  - 162
EDAT- 1992/03/04 00:00
MHDA- 1992/03/04 00:01
CRDT- 1992/03/04 00:00
PHST- 1992/03/04 00:00 [pubmed]
PHST- 1992/03/04 00:01 [medline]
PHST- 1992/03/04 00:00 [entrez]
AID - 10.1007/BF02385000 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 1992 Mar 4;110(1):1-15. doi: 10.1007/BF02385000.