PMID- 1316084
OWN - NLM
STAT- MEDLINE
DCOM- 19920611
LR  - 20181113
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 140
IP  - 5
DP  - 1992 May
TI  - Distinctive patterns of hyperplasia in transgenic mice with mouse mammary tumor 
      virus transforming growth factor-alpha. Characterization of mammary gland and 
      skin proliferations.
PG  - 1131-46
AB  - Eight lines of transgenic mice expressing a mouse mammary tumor virus (MMTV) 
      human transforming growth factor-alpha (TGF alpha) fusion gene were established. 
      Three lines with distinctive phenotypes are presented. All have proliferative 
      changes of the mammary gland. One line has sebaceous gland hyperplasia of the 
      skin. Five histologic patterns of mammary gland hyperplasia based on two of these 
      lines were identified: cystic hyperplasia, solid hyperplasia, dysplasia, adenoma, 
      and adenocarcinoma. Human TGF alpha mRNA and protein were produced in all 
      patterns but appeared reduced in solid hyperplasia, dysplasia, and 
      adenocarcinoma. TGF alpha immunoreactivity in the mammary tissue, cystic fluid, 
      and serum did not show significant differences; hyperplasia developed in 65% of 
      multiparous mice and 45% of virgin mice by 12 months of age. Adenocarcinoma 
      developed in 40% of multiparous mice and 30% of virgin mice by 16 months of age. 
      These transgenic lines may provide useful models of mammary and sebaceous gland 
      hyperplasia analogous to human disease.
FAU - Halter, S A
AU  - Halter SA
AD  - Department of Pathology, Vanderbilt University, Nashville, Tennessee 37232-2561.
FAU - Dempsey, P
AU  - Dempsey P
FAU - Matsui, Y
AU  - Matsui Y
FAU - Stokes, M K
AU  - Stokes MK
FAU - Graves-Deal, R
AU  - Graves-Deal R
FAU - Hogan, B L
AU  - Hogan BL
FAU - Coffey, R J
AU  - Coffey RJ
LA  - eng
GR  - CA 46413/CA/NCI NIH HHS/United States
GR  - CA 48799/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (RNA, Messenger)
RN  - 0 (Transforming Growth Factor alpha)
SB  - IM
MH  - Animals
MH  - Cysts/metabolism/pathology
MH  - Hyperplasia
MH  - Immunohistochemistry
MH  - Mammary Glands, Animal/*pathology
MH  - Mammary Tumor Virus, Mouse/*metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - Microscopy, Electron
MH  - Nucleic Acid Hybridization
MH  - RNA, Messenger/metabolism
MH  - Radioimmunoassay
MH  - Skin/*pathology
MH  - Transforming Growth Factor alpha/genetics/*metabolism
PMC - PMC1886506
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
PMCR- 1992/11/01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
PHST- 1992/11/01 00:00 [pmc-release]
PST - ppublish
SO  - Am J Pathol. 1992 May;140(5):1131-46.