PMID- 1316487
OWN - NLM
STAT- MEDLINE
DCOM- 19920616
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 66
IP  - 6
DP  - 1992 Jun
TI  - Genomic variation and segregation of equine infectious anemia virus during acute 
      infection.
PG  - 3879-82
AB  - Equine infectious anemia virus (EIAV) is a lentivirus that infects and persists 
      in the monocyte/macrophage populations of blood and tissues. We employed 
      polymerase chain reaction to investigate the distribution and the level of genome 
      variability of EIAV DNA in different tissues of a horse infected with a highly 
      virulent variant of the Wyoming strain of the virus. Long terminal repeat, gag, 
      and pol primer pairs were used to direct the amplification of EIAV DNA from the 
      peripheral blood mononuclear cells and from cells, presumably the macrophage 
      subtypes, of the kidney, spleen, liver, lymph node, and cerebellum and 
      periventricular regions of the brain. Polymerase chain reaction analysis of four 
      domains within the envelope showed that viral subtypes with particular envelope 
      domains segregated to different tissues as defined by the presence or absence of 
      a given type of domain. Collectively, these results show that virus variants in 
      the env gene home to different tissues, presumably because of selection for 
      tissue-specific envelope determinants.
FAU - Kim, C H
AU  - Kim CH
AD  - Department of Microbiology, Immunology, and Parasitology, College of Veterinary 
      Medicine, Cornell University, Ithaca, New York 14853.
FAU - Casey, J W
AU  - Casey JW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Equine Infectious Anemia/*genetics
MH  - Genes, env/*genetics
MH  - Genetic Variation
MH  - Horses
MH  - Infectious Anemia Virus, Equine/classification/*genetics/pathogenicity
MH  - Molecular Sequence Data
MH  - Organ Specificity/genetics
MH  - Polymerase Chain Reaction
PMC - PMC241174
EDAT- 1992/06/01 00:00
MHDA- 1992/06/01 00:01
PMCR- 1992/06/01
CRDT- 1992/06/01 00:00
PHST- 1992/06/01 00:00 [pubmed]
PHST- 1992/06/01 00:01 [medline]
PHST- 1992/06/01 00:00 [entrez]
PHST- 1992/06/01 00:00 [pmc-release]
AID - 10.1128/JVI.66.6.3879-3882.1992 [doi]
PST - ppublish
SO  - J Virol. 1992 Jun;66(6):3879-82. doi: 10.1128/JVI.66.6.3879-3882.1992.