PMID- 1316806
OWN - NLM
STAT- MEDLINE
DCOM- 19920623
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 69
IP  - 4
DP  - 1992 May 15
TI  - Transgenic mouse mammary tumor virus superantigen expression prevents viral 
      infection.
PG  - 637-45
AB  - Endogenous mouse mammary tumor virus (MMTV) proviruses have recently been shown 
      to cosegregate genetically with the minor lymphocyte-stimulating loci, also 
      termed self-superantigens. The antigenic activity has been localized to the open 
      reading frame (ORF) protein encoded in the long terminal repeat of MMTV. We show 
      here that unlike their nontransgenic littermates, transgenic mice expressing high 
      levels of an ORF protein derived from the C3H exogenous MMTV specifically delete 
      their V beta 14+ T cells and do not become infected with this virus when it is 
      present in their mother's milk. Thus, it appears that MMTV utilizes cells of the 
      immune system in its infection pathway, and mice that retain endogenous MMTVs 
      should be immune to infection by exogenous virus. These results offer possible 
      new approaches to anti-viral therapy or immunization.
FAU - Golovkina, T V
AU  - Golovkina TV
AD  - Department of Biochemistry, University of Illinois College of Medicine, Chicago 
      60612.
FAU - Chervonsky, A
AU  - Chervonsky A
FAU - Dudley, J P
AU  - Dudley JP
FAU - Ross, S R
AU  - Ross SR
LA  - eng
GR  - R01 CA34780/CA/NCI NIH HHS/United States
GR  - R01 CA45954/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Antigens, Viral)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
SB  - IM
MH  - Animals
MH  - Antigens, Viral/genetics/*immunology
MH  - Gene Expression
MH  - Lymphocyte Depletion
MH  - Mammary Tumor Virus, Mouse/genetics/*immunology
MH  - Mice
MH  - Mice, Transgenic
MH  - RNA, Messenger/genetics
MH  - Receptors, Antigen, T-Cell, alpha-beta/genetics
MH  - Repetitive Sequences, Nucleic Acid
MH  - T-Lymphocytes/*immunology
MH  - Tumor Virus Infections/*immunology
EDAT- 1992/05/15 00:00
MHDA- 1992/05/15 00:01
CRDT- 1992/05/15 00:00
PHST- 1992/05/15 00:00 [pubmed]
PHST- 1992/05/15 00:01 [medline]
PHST- 1992/05/15 00:00 [entrez]
AID - 0092-8674(92)90227-4 [pii]
AID - 10.1016/0092-8674(92)90227-4 [doi]
PST - ppublish
SO  - Cell. 1992 May 15;69(4):637-45. doi: 10.1016/0092-8674(92)90227-4.