PMID- 1316885
OWN - NLM
STAT- MEDLINE
DCOM- 19920623
LR  - 20171116
IS  - 0300-9831 (Print)
IS  - 0300-9831 (Linking)
VI  - 62
IP  - 1
DP  - 1992
TI  - Dietary modulators of lipid metabolism in the Indian diet-heart study (I.D.H.S.).
PG  - 73-82
AB  - Of the 621 adults (25 to 65 years of age, 531 males) with either risk factors or 
      with coronary heart disease (CHD) 310 subjects were given a cardiovasoprotective 
      (CVP) diet (group A) and 311 subjects a normal diet (group B) in a randomized, 
      single blind and controlled fashion. Risk factors and incidence of CHD were 
      comparable between the two groups. The intervention group received a 
      significantly higher percentage of calories in relation to complex carbohydrates, 
      vegetable proteins, polyunsaturated fatty acids and high P:S ratio diet as 
      compared to the control group. The control group received higher saturated fat 
      and cholesterol. Compliance was assessed by dietary questionnaire during the 
      follow-up. After 8 weeks of dietary trial, there was a significant decrease in 
      mean serum total cholesterol (8.2 vs 2.1%), low density lipoprotein (LDL) 
      cholesterol (9.8 vs. 2.7%) and triglyceride (11.2 vs 5.8%) in the intervention 
      group compared to baseline levels and changes in control subjects. Body weight 
      and physical activity at the entry to study and during the trial were similar in 
      both groups. The decrease in mean HDL cholesterol were insignificant both in the 
      intervention (4.3%) and control group (5.0%). There were no adverse effects of 
      diet during the 8 weeks of trial. It is possible that a diet with 27.5% energy 
      from total fat including 10.1% energy from monounsaturated fatty acids, P:S ratio 
      1.38, 120 mg dietary cholesterol, 26.0 g dietary fibre per 1000 kcal would 
      modulate the lipid metabolism resulting in a significant reduction in serum total 
      cholesterol, LDL cholesterol and triglyceride with no reduction in HDL 
      cholesterol. This diet may be capable of reducing CHD incidence and mortality in 
      the long term Indian diet-heart study (IDHS).
FAU - Singh, R B
AU  - Singh RB
AD  - Medical Hospital and Research Centre, Moradabad, India.
FAU - Sircar, A R
AU  - Sircar AR
FAU - Singh, R G
AU  - Singh RG
FAU - Mani, U V
AU  - Mani UV
FAU - Seth, J
AU  - Seth J
FAU - Devi, L
AU  - Devi L
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Switzerland
TA  - Int J Vitam Nutr Res
JT  - International journal for vitamin and nutrition research. Internationale 
      Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de 
      vitaminologie et de nutrition
JID - 1273304
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Fiber)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Coronary Disease/*diet therapy/epidemiology/etiology
MH  - Dietary Fats/*administration & dosage
MH  - Dietary Fiber/*administration & dosage
MH  - Edible Grain
MH  - Fruit
MH  - Humans
MH  - India/epidemiology
MH  - Middle Aged
MH  - Risk Factors
MH  - Vegetables
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Int J Vitam Nutr Res. 1992;62(1):73-82.