PMID- 1317222
OWN - NLM
STAT- MEDLINE
DCOM- 19920626
LR  - 20190509
IS  - 0006-3363 (Print)
IS  - 0006-3363 (Linking)
VI  - 46
IP  - 5
DP  - 1992 May
TI  - Tumor necrosis factor-alpha stimulates the biosynthesis of matrix 
      metalloproteinases and plasminogen activator in cultured human chorionic cells.
PG  - 772-8
AB  - To investigate the role of tumor necrosis factor-alpha (TNF alpha) in advanced 
      collagenolysis and degradation of connective tissue components in preterm 
      parturition, the effects of human recombinant TNF alpha (hrTNF alpha) on the 
      production of matrix metalloproteinase 1 (MMP-1)/tissue collagenase, 
      MMP-3/stromelysin, tissue inhibitor of metalloproteinases (TIMP), urokinase 
      type-plasminogen activator (uPa) and prostaglandin (PG) E2 in human chorionic 
      cells were examined in vitro. Human chorionic cells, but not amniotic cells, were 
      found to respond to macrophage-conditioned medium (contains mainly interleukin 1) 
      to produce MMP-1 and MMP-3. This indicated that the chorionic cell is one of the 
      MMP-producing cells of fetal membranes. When confluent chorionic cells were 
      treated with hrTNF alpha, the production of MMP-1 and MMP-3 as well as of uPa and 
      PGE2 was greatly increased in a dose-dependent manner. In contrast, the 
      production of TIMP was suppressed by hrTNF alpha. These results suggested that 
      TNF alpha may participate in destruction of collagen and other connective tissue 
      matrix components of fetal membranes and in promotion of uterine contractility in 
      preterm parturition with intraamniotic infection.
FAU - So, T
AU  - So T
AD  - Department of Obstetrics and Gynecology, School of Medicine, Toho University, 
      Tokyo, Japan.
FAU - Ito, A
AU  - Ito A
FAU - Sato, T
AU  - Sato T
FAU - Mori, Y
AU  - Mori Y
FAU - Hirakawa, S
AU  - Hirakawa S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biol Reprod
JT  - Biology of reproduction
JID - 0207224
RN  - 0 (Glycoproteins)
RN  - 0 (Plasminogen Inactivators)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-34-5 (Collagen)
RN  - EC 3.4.21.- (Plasminogen Activators)
RN  - EC 3.4.21.73 (Urokinase-Type Plasminogen Activator)
RN  - EC 3.4.24.3 (Microbial Collagenase)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
SB  - IM
MH  - Amnion/drug effects/metabolism
MH  - Cells, Cultured
MH  - Chorion/*drug effects/metabolism
MH  - Collagen/metabolism
MH  - Connective Tissue/metabolism
MH  - Female
MH  - Glycoproteins/biosynthesis
MH  - Humans
MH  - Matrix Metalloproteinase 1
MH  - Microbial Collagenase/antagonists & inhibitors/*biosynthesis
MH  - Plasminogen Activators/*biosynthesis
MH  - Plasminogen Inactivators/metabolism
MH  - Pregnancy
MH  - Recombinant Proteins/pharmacology
MH  - Tissue Inhibitor of Metalloproteinases
MH  - Tumor Necrosis Factor-alpha/*pharmacology
MH  - Urokinase-Type Plasminogen Activator/biosynthesis
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
AID - 10.1095/biolreprod46.5.772 [doi]
PST - ppublish
SO  - Biol Reprod. 1992 May;46(5):772-8. doi: 10.1095/biolreprod46.5.772.