PMID- 1317553
OWN - NLM
STAT- MEDLINE
DCOM- 19920702
LR  - 20051117
IS  - 0344-0338 (Print)
IS  - 0344-0338 (Linking)
VI  - 188
IP  - 1-2
DP  - 1992 Feb
TI  - Malignant renal tumors of childhood.
PG  - 1-15
AB  - The prognosis in nephroblastoma (Wilms' tumor) has been improved considerably by 
      treatment protocols combining surgery, chemotherapy, radiation therapy, and, in 
      some clinical trials, pre-operative chemotherapy. Cure is now achieved in most 
      patients. All clinical trials have employed treatment strategies tailored to the 
      individual risk of the patient, including the histological subtype of the tumor. 
      In the National Wilms' Tumor Study (NWTS) of the United States these subtypes 
      have been divided into two groups of tumors according to their "favorable" or 
      "unfavorable" histology. At the Kiel Pediatric Tumor Registry we have devised a 
      system which distinguishes three groups of tumors classified according to 
      prognosis. The first group includes tumors with a favorable prognosis, even if 
      only surgery is performed. These comprise congenital mesoblastic nephroma (CMN) 
      and cystic, partially differentiated nephroblastoma (CPDN). The second group 
      consists of tumors posing an intermediate risk, such as typical nephroblastoma 
      and its histological variants characterized by variations in the relative 
      proportions of the histological components. Fetal rhabdomyomatous nephroblastoma 
      (FRN) is also included in this group. The third group comprises tumors of high 
      risk such as anaplastic nephroblastoma, clear cell sarcoma of the kidney (CCSK), 
      and malignant rhabdoid tumor of the kidney (MRTK). Since histological diagnosis 
      plays a crucial role in the assignment of a patient to a particular type of 
      treatment protocol, knowledge of the histological appearance of the various tumor 
      types both with and without preoperative treatment is of utmost importance.
FAU - Schmidt, D
AU  - Schmidt D
AD  - Institute of Pathology, Christian Albrechts University, Kiel, FRG.
FAU - Harms, D
AU  - Harms D
FAU - Leuschner, I
AU  - Leuschner I
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/therapeutic use
MH  - Carcinoma, Renal Cell/pathology
MH  - Child
MH  - Combined Modality Therapy
MH  - Diagnosis, Differential
MH  - Humans
MH  - Kidney Neoplasms/classification/*pathology/therapy
MH  - Preoperative Care/methods
MH  - Prognosis
MH  - Retrospective Studies
MH  - Wilms Tumor/pathology
EDAT- 1992/02/01 00:00
MHDA- 1992/02/01 00:01
CRDT- 1992/02/01 00:00
PHST- 1992/02/01 00:00 [pubmed]
PHST- 1992/02/01 00:01 [medline]
PHST- 1992/02/01 00:00 [entrez]
AID - S0344-0338(11)81150-7 [pii]
AID - 10.1016/S0344-0338(11)81150-7 [doi]
PST - ppublish
SO  - Pathol Res Pract. 1992 Feb;188(1-2):1-15. doi: 10.1016/S0344-0338(11)81150-7.